Natsume O, Ozono S, Tsumatani K, Yoshikawa M, Sasaki K, Hirao Y, Okajima E
Department of Urology, Nara Medical University.
Jpn J Clin Oncol. 1989 Mar;19(1):72-4.
The present report describes two cases of seminoma that occurred simultaneously in non-twin brothers. These siblings were typed for HLA-A, -B, -C and -DR specificities, and manifested identical haplotypes. Sixty-four sets of affected siblings have been reported prior to the present cases. We examined HLA-DR antigen in brothers with testicular tumors and hereditary roles in the etiology are discussed.
本报告描述了非双胞胎兄弟同时发生精原细胞瘤的两例病例。对这些兄弟进行了HLA - A、- B、- C和 - DR特异性分型，结果显示他们具有相同的单倍型。在本病例之前已报告过64组患病兄弟。我们检测了患有睾丸肿瘤的兄弟中的HLA - DR抗原，并讨论了其在病因学中的遗传作用。
