Dieckmann K P, von Keyserlingk H J
Urologische Klinik, Freien Universität Berlin.
Klin Wochenschr. 1988 Apr 15;66(8):337-9. doi: 10.1007/BF01735790.
Clinical and epidemiological studies suggest that genetic factors may be involved in the etiology and pathogenesis of testicular germ-cell tumors (GCTs). Previous HLA studies have tried to support the concept of genetic anticipation of GCTs, however, the results obtained have been inconsistent. The reasons for the divergent results are mainly statistical problems, i.e., small patient populations, high numbers of antigens tested, and inhomogeneous study populations. In the present retrospective study, 52 patients with histologically pure seminoma were typed for their HLA-A, B, C, and DR antigens. Only BW41 proved to be significantly increased in frequency after correction for the number of antigens tested (chi Q = 12.73; P = 0.0005). HLA-DR1 was shown to be decreased, however, the difference was not significant. Regarding metastatic seminoma alone, there was a trend towards an increase of A29, BW41, and DR7. Our study gives only weak evidence for the participation of genetic factors in the pathogenesis of seminoma. The statistical trend of HLA association observed in metastatic seminoma deserves further concern as does the question of whether MHC class II antigens are also involved in the pathogenesis of testicular seminoma.
临床和流行病学研究表明，遗传因素可能参与睾丸生殖细胞肿瘤（GCT）的病因学和发病机制。以往的HLA研究试图支持GCT遗传预期的概念，然而，所获得的结果并不一致。结果存在差异的主要原因是统计学问题，即患者群体规模小、检测的抗原数量多以及研究群体不均匀。在本回顾性研究中，对52例组织学上为纯精原细胞瘤的患者进行了HLA - A、B、C和DR抗原分型。经检测抗原数量校正后，仅BW41的频率显著增加（卡方值Q = 12.73；P = 0.0005）。HLA - DR1显示频率降低，然而，差异不显著。仅就转移性精原细胞瘤而言，A29、BW41和DR7有增加的趋势。我们的研究仅提供了微弱的证据证明遗传因素参与精原细胞瘤的发病机制。在转移性精原细胞瘤中观察到的HLA关联的统计学趋势值得进一步关注，MHC II类抗原是否也参与睾丸精原细胞瘤的发病机制这一问题同样值得关注。
