Habermann E, Müller B
Rudolf-Buchheim-Institut für Pharmakologie, Justus-Liebig-Universität, Giessen.
Klin Wochenschr. 1989 Jan 4;67(1):20-5. doi: 10.1007/BF01736530.
Oxoferin, a preparation approved for wound treatment, has been subjected to an in vitro analysis. 1. Oxoferin produces methaemoglobin even if diluted 500 fold, and leads to additional alterations if added in high concentrations to red cells. Sodium chlorite (NaClO2, 15 mM) is equivalent to undiluted Oxoferin. 2. Oxoferin in fiftyfold dilution damages fibroblasts in cell culture slowly and persistently. This dilution is equieffective with a 200 microM solution of sodium chlorite. Oxoferin and sodium chlorite also damage vascular endothelial cells. 3. The oxidation equivalent of Oxyoferin is 12.3 mM sodium chlorite. Our data indicate that Oxoferin may be equated essentially with aqueous sodium chlorite.
奥索铁林是一种已获批准用于伤口治疗的制剂，现已进行了体外分析。1. 奥索铁林即使稀释500倍也会产生高铁血红蛋白，若以高浓度添加到红细胞中会导致其他变化。亚氯酸钠（NaClO2，15 mM）与未稀释的奥索铁林等效。2. 五十倍稀释的奥索铁林会在细胞培养中缓慢且持续地损伤成纤维细胞。这种稀释度与200 microM的亚氯酸钠溶液效果相当。奥索铁林和亚氯酸钠也会损伤血管内皮细胞。3. 奥索铁林的氧化当量为12.3 mM亚氯酸钠。我们的数据表明，奥索铁林基本上可等同于亚氯酸钠水溶液。
