Mergenthaler H G, Fink M, Sauer H, Bartl R, Wilmanns W
Gesellschaft für Strahlen- und Umweltforschung, Institut für Experimentelle Hämatologie, München.
Klin Wochenschr. 1989 Jan 4;67(1):42-6. doi: 10.1007/BF01736534.
For years, brown tumors have been considered to be a characteristic of primary hyperparathyroidism. However, since 1963 several reports indicate the incidence of brown tumors in patients with renal secondary hyperparathyroidism to be 1.5%-1.7%. The appearance of multiple brown tumor lesions is rather uncommon in secondary hyperparathyroidism which is also true for malabsorption as its cause. We report on a 56-year-old man presenting with pain in the bones and multiple osteolyses. A bone biopsy specimen and the laboratory examinations were indicative of secondary hyperparathyroidism caused by malabsorption most likely due to Billroth's II/I gastric resection. Thus, the patient's osteolyses represent brown tumors which have been induced by nutritional secondary hyperparathyroidism.
多年来，棕色瘤一直被认为是原发性甲状旁腺功能亢进的一个特征。然而，自1963年以来，几份报告表明，肾性继发性甲状旁腺功能亢进患者中棕色瘤的发生率为1.5%-1.7%。多发性棕色瘤病变在继发性甲状旁腺功能亢进中相当少见，由吸收不良作为病因时亦是如此。我们报告一名56岁男性，表现为骨痛和多处骨质溶解。骨活检标本和实验室检查表明，其继发性甲状旁腺功能亢进是由吸收不良引起的，很可能是由于毕罗Ⅱ式/Ⅰ式胃切除术。因此，该患者的骨质溶解代表了由营养性继发性甲状旁腺功能亢进诱发的棕色瘤。
