Post-graduate program in Dentistry at Federal University of Ceará in Ceará, Brazil.
Med Oral Patol Oral Cir Bucal. 2010 Jan 1;15(1):e10-3.
Tertiary Hyperparathyroidism (HPT) is an uncommon condition that affects patients with secondary HPT after a successful kidney transplant. Bone alterations are the main consequences of this endocrine condition, including the development of an osteolytic lesion called brown tumour. This paper reports an unusual case of multiple brown tumours located in the maxilla and mandible in a 58-year-old renal transplant recipient, with tertiary HPT. Incisional biopsies were performed and, in both samples, the histopathological diagnoses were giant cell lesions. Due to these diagnoses, the medical history of chronic renal failure, and high levels of serum calcium and PTH, lesions were diagnosed as multiple brown tumours of tertiary HPT. The lesions showed regression within the two months following a total parathyroidectomy. Minimal local interventions were established to make an early diagnosis and to treat these lesions. The diagnosis of primary oral lesions was very important in order to demonstrate the relevance of interdisciplinary activity and the inclusion of dentists as part of organ transplant units.
三发性甲状旁腺功能亢进症（HPT）是一种罕见的疾病，影响接受成功肾移植后的继发性 HPT 患者。这种内分泌疾病的主要后果是骨骼改变，包括发展为溶骨性病变，称为棕色瘤。本文报告了一例 58 岁肾移植受者的罕见病例，该患者患有三发性 HPT，上颌和下颌有多发性棕色瘤。进行了切开活检，在两个样本中，组织病理学诊断均为巨细胞病变。由于这些诊断、慢性肾衰竭的病史以及血清钙和 PTH 水平升高，诊断为三发性 HPT 的多发性棕色瘤。甲状旁腺全切除术后两个月内，病变出现消退。建立了最小的局部干预措施，以进行早期诊断和治疗这些病变。为了证明跨学科活动的相关性以及将牙医纳入器官移植单位的一部分，对原发性口腔病变的诊断非常重要。
