Li Meng-Wen, Fan Xin-Sheng, Zhang Ling-Shan, Wang Cong-Jun
Institute of Traditional Chinese Medicine Literature Research, Nanjing University of Chinese Medicine, Nanjing 210023, China.
School of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhongguo Zhong Yao Za Zhi. 2017 Sep;42(18):3623-3627. doi: 10.19540/j.cnki.cjcmm.2017.0140.
The applications of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung in contemporary literatures from 1949 to 2016 are compiled and the data mining techniques containing scale-free complex network method are utilized to explore its practical characteristics, with comparison between modern and ancient ones. The results indicate that malignant neoplasms, coronary heart disease which present Qi deficiency and blood stasis type are the main diseases treated by prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung according to the reports during 1949 to 2016. The complex network connection shows that Glycyrrhizae Radixet Rhizoma, Angelicae Sinensis Radix, Astragali Radix, Typhae Pollen, Salviae Miltiorrhizae Radix et Rhizoma are the primary drugs related to Ginseng Radix et Rhizoma and Trogopterus Dung. The next are Paeoniae Radix Alba, Atractylodis Macrocephalae Rhizoma, Persicae Semen, Foria, et al. Carthami Flos, Notoginseng Radix et Rhizoma, Cyperi Rhizoma, Bupleuri Radix are the peripheral ones. Also, Ginseng Radix et Rhizoma-Glycyrrhizae Radixet Rhizoma, Trogopterus Dung-Glycyrrhizae Radixet Rhizoma, Ginseng Radix et Rhizoma-Angelicae Sinensis Radix, Trogopterus Dung-Angelicae Sinensis Radix, Ginseng Radix et Rhizoma-Astragali Radix, Trogopterus Dung-Astragali Radix are the main paired drugs. The paired drugs including Ginseng Radix et Rhizoma-Trogopterus Dung-Glycyrrhizae Radixet Rhizoma, Ginseng Radix et Rhizoma-Trogopterus Dung-Angelicae Sinensis Radix, Ginseng Radix et Rhizoma-Trogopterus Dung-Astragali Radix, Ginseng Radix et Rhizoma-Trogopterus Dung-Typhae Pollen have a higher support degree. The main compatible drugs are different in ancient and modern prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung. Notoginseng Radix et Rhizoma, Typhae Pollen, Salviae Miltiorrhizae Radix et Rhizoma, Astragali Radix are utilized frequently in modern prescriptions while less used in ancient ones. It is also shown that more attentions are paid to the drugs contributing to invigorating Qi and promoting blood circulation in modern times with comparative results between modern and ancient prescriptions.
对1949年至2016年当代文献中含人参和五灵脂的方剂应用进行整理，并运用包括无标度复杂网络方法在内的数据挖掘技术探索其用药特点，并对古今用药进行比较。结果表明，根据1949年至2016年的报道，恶性肿瘤、气虚血瘀型冠心病是含人参和五灵脂方剂治疗的主要疾病。复杂网络关联显示，甘草、当归、黄芪、蒲黄、丹参是与人参和五灵脂相关的主要药物。其次是白芍、白术、桃仁、茯苓等。红花、三七、香附、柴胡是外围药物。此外，人参-甘草、五灵脂-甘草、人参-当归、五灵脂-当归、人参-黄芪、五灵脂-黄芪是主要的药对。含人参-五灵脂-甘草、人参-五灵脂-当归、人参-五灵脂-黄芪、人参-五灵脂-蒲黄的药对支持度较高。含人参和五灵脂的古今方剂中主要配伍药物有所不同。三七、蒲黄、丹参、黄芪在现代方剂中使用频繁，而在古代方剂中使用较少。古今方剂比较结果还显示，现代更注重补气活血类药物。
