INSERM U979, Institut Langevin, Paris, France. ESPCI Paris, Institut Langevin, PSL Research University, Paris, France. CNRS UMR 7587, Institut Langevin, Paris, France. Université Paris Diderot, Paris, France.
Phys Med Biol. 2018 Jan 16;63(2):025026. doi: 10.1088/1361-6560/aaa037.
The development of multi-element arrays for better control of the shape of ultrasonic beams has opened the way for focusing through highly aberrating media, such as the human skull. As a result, the use of brain therapy with transcranial-focused ultrasound has rapidly grown. Although effective, such technology is expensive. We propose a disruptive, low-cost approach that consists of focusing a 1 MHz ultrasound beam through a human skull with a single-element transducer coupled with a tailored silicone acoustic lens cast in a 3D-printed mold and designed using computed tomography-based numerical acoustic simulation. We demonstrate on N = 3 human skulls that adding lens-based aberration correction to a single-element transducer increases the deposited energy on the target 10 fold.
多元素阵列的发展为更好地控制超声波束的形状开辟了道路，使得能够通过高度像差介质（如人类颅骨）进行聚焦。因此，经颅聚焦超声的脑部治疗技术得到了快速发展。尽管这种技术有效，但成本很高。我们提出了一种具有颠覆性的低成本方法，该方法使用单个元件换能器聚焦 1 MHz 超声波束，该换能器与定制的硅酮声透镜耦合，该声透镜采用 3D 打印模具铸造，并使用基于计算机断层扫描的数值声学模拟进行设计。我们在 3 个人颅骨上进行了演示，结果表明，在单个元件换能器上添加基于透镜的像差校正可将目标上的沉积能量增加 10 倍。
