有先兆偏头痛伴永存卵圆孔未闭。
Migraine with aura and persistent foramen ovale.
机构信息
Royal Stoke University Hospital, Stoke-on-Trent, UK.
出版信息
Eye (Lond). 2018 Feb;32(2):184-188. doi: 10.1038/eye.2017.269. Epub 2017 Dec 8.
Abstract
The association between migraine with aura and persistent foramen ovale (PFO), as well as other right-to-left shunts, is described. A hypothesis that might explain this association is discussed. Observational studies suggested that when a PFO is closed patients who have migraine with aura are usually improved. The Migraine Intervention with STARFlex Technology (MIST) Trial was a randomised double-blind trial in patients with severe intractable migraine with aura and a moderate-large PFO that compared implantation of STARFlex devices with the intention of closing their PFO versus a sham procedure. It was hoped that the trial would demonstrate whether PFO closure would cure migraine. A series of problems in design and execution of the trial are discussed.
摘要
偏头痛先兆与卵圆孔未闭（PFO）以及其他右向左分流之间的关联已被描述。本文讨论了一种可能的解释该关联的假说。观察性研究表明，当 PFO 关闭时，偏头痛先兆患者通常会得到改善。采用 STARFlex 技术的偏头痛干预（MIST）试验是一项针对严重难治性偏头痛先兆且存在中大型 PFO 的患者进行的随机双盲试验，该试验比较了 STARFlex 装置植入以关闭 PFO（实验组）与假手术（对照组）对偏头痛的治疗效果，试验旨在证实 PFO 关闭是否能治愈偏头痛。本文讨论了该试验在设计和实施过程中出现的一系列问题。
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