Oh Hye Kyung, Lee Jee Young, Eo Wan Kyu, Yoon Seong Woo, Han Sung Nim
a Department of Food and Nutrition , College of Human Ecology, Seoul National University , Seoul , Republic of Korea.
b Department of Internal Medicine , Korean Medicine Cancer Center, Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
Nutr Cancer. 2018 Jan;70(1):37-44. doi: 10.1080/01635581.2018.1397711. Epub 2017 Dec 8.
Serum vitamin B levels have been proposed as one of the survival prediction factors, although no survival analysis in metastatic cancer patients has been conducted yet. This study examined whether serum vitamin B levels could be a prognostic factor in metastatic cancer patients.
Data from a retrospective chart review were used to perform Kaplan-Meier and multivariate analyses of the Cox proportional hazards. Subgroup analysis was performed on patients without a liver lesion (hepatocellular carcinoma or liver metastasis).
A total of 523 patients were included. The median survival time was 1.8 months (mo) in the high B group (>911 pg/mL) and 5.1 mo in the normal B group (211-911 pg/mL) (p < 0.001). In patients without a liver lesion, the median survival times were 2.1 and 6.1 mo in the high and normal B groups, respectively (p < 0.001). Multivariate analysis revealed that serum vitamin B level was an independent prognostic factor for overall survival (hazard ratio [HR]: 1.62; 95% confidence interval [CI]: 1.34-1.96, p < 0.001).
Serum vitamin B level can be used to predict survival time in metastatic cancer patients. Further large-scale cohort studies are required to confirm these findings.
血清维生素B水平已被提出作为生存预测因素之一，尽管尚未对转移性癌症患者进行生存分析。本研究探讨血清维生素B水平是否可作为转移性癌症患者的预后因素。
回顾性病历审查数据用于进行Kaplan-Meier分析和Cox比例风险多变量分析。对无肝脏病变（肝细胞癌或肝转移）的患者进行亚组分析。
共纳入523例患者。高B组（>911 pg/mL）的中位生存时间为1.8个月（mo），正常B组（211 - 911 pg/mL）为5.1 mo（p < 0.001）。在无肝脏病变的患者中，高B组和正常B组的中位生存时间分别为2.1 mo和6.1 mo（p < 0.001）。多变量分析显示，血清维生素B水平是总生存的独立预后因素（风险比[HR]：1.62；95%置信区间[CI]：1.34 - 1.96，p < 0.001）。
血清维生素B水平可用于预测转移性癌症患者的生存时间。需要进一步的大规模队列研究来证实这些发现。
