Döngel İsa, Akbaş Ali, Benli İsmail, Bayram Mehmet
Department of Thoracic Surgery, Süleyman Demirel University Medical Faculty, Isparta, Turkey.
Department of Clinical Biochemistry, Ataturk State Hospital, Balıkesir, Turkey.
Turk Gogus Kalp Damar Cerrahisi Derg. 2019 Jun 28;27(3):374-380. doi: 10.5606/tgkdc.dergisi.2019.17557. eCollection 2019 Jul.
In this study, we aimed to compare serum biochemical markers in patients with malignant pleural mesothelioma and pleural plaques versus healthy individuals exposed to environmental asbestos.
Between September 01, 2010 and March 31, 2011, a total of 540 participants (354 males, 186 females; mean age 61.4 years; range, 35 to 89 years) were included in the study. The participants were divided into four groups as follows: (1) patients with pleural plaques (n=277); (2) healthy individuals with normal chest X-rays who were exposed to environmental asbestos (n=121); (3) healthy individuals with normal chest X-rays who were not exposed to environmental asbestos (n=118); and (4) patients with malignant pleural mesothelioma (n=24). Serum levels of carcinoembryonic antigen, cancer antigen 125, 15-3, 19-9, free T3, free T4, thyroidstimulating hormone, vitamin B12, folate, and ferritin were measured.
Serum cancer antigen 125, 15-3, folic acid, vitamin B12, and ferritin levels were higher with lower free T3 levels in Group 4 than the other groups. The areas under the curve for cancer antigen 125 and 15-3 were 0.78 and 0.67, respectively in the differential diagnosis of mesothelioma from other pathologies (p<0.001 for both). Optimal limits of these biomarkers were 13.63 and 18.43 ng/mL, respectively with 83% and 75% sensitivity and 69% and 48% specificity, respectively.
The combination or individual use of serum cancer antigen 125, 15-3, folic acid, vitamin B12, and ferritin levels may be helpful for early diagnosis and treatment of malignant pleural mesothelioma.
在本研究中，我们旨在比较恶性胸膜间皮瘤患者、胸膜斑患者与暴露于环境石棉的健康个体的血清生化标志物。
2010年9月1日至2011年3月31日期间，共有540名参与者（354名男性，186名女性；平均年龄61.4岁；范围35至89岁）纳入本研究。参与者被分为以下四组：（1）胸膜斑患者（n = 277）；（2）胸部X线正常且暴露于环境石棉的健康个体（n = 121）；（3）胸部X线正常且未暴露于环境石棉的健康个体（n = 118）；（4）恶性胸膜间皮瘤患者（n = 24）。检测血清癌胚抗原、癌抗原125、15 - 3、19 - 9、游离T3、游离T4、促甲状腺激素、维生素B12、叶酸和铁蛋白水平。
第4组血清癌抗原125、15 - 3、叶酸、维生素B12和铁蛋白水平较高，游离T3水平较低，高于其他组。在间皮瘤与其他病理情况的鉴别诊断中，癌抗原125和15 - 3的曲线下面积分别为0.78和0.67（两者p均<0.001）。这些生物标志物的最佳界限分别为13.63和18.43 ng/mL，敏感性分别为83%和75%，特异性分别为69%和48%。
血清癌抗原125、15 - 3、叶酸、维生素B12和铁蛋白水平的联合或单独使用可能有助于恶性胸膜间皮瘤的早期诊断和治疗。
