Kamakura Takefumi, Nadol Joseph B
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, and Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
Audiol Neurootol. 2017;22(4-5):218-225. doi: 10.1159/000481279. Epub 2017 Dec 9.
Bone remodeling within the otic capsule has been reported to be inhibited especially at or near the cochlea, except under some pathological conditions such as otosclerosis, Paget's disease, or mastoiditis, when bone remodeling can occur. Microcavitations found in periosteal and endosteal layers of human temporal bone specimens without otosclerosis, Paget's disease, or inflammation as reported in the current study are consistent with osteoclastic bone resorption. Thirty-three temporal bones from 33 patients were prepared for light microscopy and classified into 4 groups: histologically proven dehiscence of the superior semicircular canal (SSCD) (n = 3, group 1), age 20 years or younger (n = 10, group 2), age 90 years or older and with otosclerosis (n = 10, group 3), and age 90 years or older without otosclerosis (n = 10, group 4). Microcavitation was seen at 7 anatomic locations in the temporal bone in all 4 groups, but not in the cochlea or vestibule. Microcavitation within the temporal bone is likely due to osteoclastic activity, and it is seen in both young and old patients, patients with and without otosclerosis, and in cases with SSCD.
据报道，耳囊内的骨重塑受到抑制，尤其是在耳蜗处或其附近，除非在某些病理情况下，如耳硬化症、佩吉特氏病或乳突炎，此时骨重塑可能会发生。如本研究报道，在没有耳硬化症、佩吉特氏病或炎症的人类颞骨标本的骨膜层和骨内膜层中发现的微腔与破骨细胞性骨吸收一致。对33例患者的33块颞骨进行了光学显微镜检查，并分为4组：组织学证实的上半规管裂开（SSCD）（n = 3，第1组）、20岁及以下（n = 10，第2组）、90岁及以上且患有耳硬化症（n = 10，第3组）、90岁及以上且无耳硬化症（n = 10，第4组）。在所有4组的颞骨7个解剖位置均可见微腔，但在耳蜗或前庭未见。颞骨内的微腔可能是由于破骨细胞活动所致，在年轻和老年患者、患有和未患有耳硬化症的患者以及患有SSCD的病例中均可见到。
