Food Science Department, and College of Food and Agriculture, United Arab Emirates University, PO Box 1555, Al Ain, United Arab Emirates.
Nutrition and Health Science Department, College of Food and Agriculture, United Arab Emirates University, PO Box 1555, Al Ain, United Arab Emirates.
J Dairy Sci. 2018 Feb;101(2):900-911. doi: 10.3168/jds.2017-13400. Epub 2017 Dec 8.
This study aimed to investigate in vitro anticancer activity by antiproliferative activity, antihypertensive activity by angiotensin-converting enzyme inhibition, antidiabetic activity by α-amylase and α-glucosidase inhibitions, and antioxidant activities of camel milk fermented with camel milk probiotic compared with fermented bovine milk. The camel milk probiotic strain Lactococcus lactis KX881782 (Lc.K782) and control Lactobacillus acidophilus DSM9126 (La.DSM) were used to prepare fermented camel and bovine milks separately. The proteolytic activities of water-soluble extract (WSE) in all fermented camel milk were higher than those in fermented bovine milk. The α-glucosidase inhibitions in both milk types fermented by Lc.K782 ranged from 30 to 40%. Camel milk fermented by Lc.K782 had the highest antioxidant activity by 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulphonic acid). The highest angiotensin-converting enzyme inhibition of WSE in camel milk fermented by Lc.K782 was >80%. The proliferations of Caco-2, MCF-7, and HELA cells were more inhibited when treated with WSE of fermented camel milk extracts.
本研究旨在通过体外增殖活性、血管紧张素转换酶抑制的降压活性、α-淀粉酶和α-葡萄糖苷酶抑制的抗糖尿病活性以及与发酵牛乳相比，骆驼乳益生菌发酵骆驼乳的抗氧化活性来进行研究。使用乳球菌 lactis KX881782 (Lc.K782) 和嗜酸乳杆菌 DSM9126 (La.DSM) 这两种骆驼乳益生菌菌株来分别制备发酵的骆驼乳和牛乳。所有发酵骆驼乳的水溶性提取物 (WSE) 的蛋白水解活性均高于发酵牛乳。两种牛奶类型由 Lc.K782 发酵的 α-葡萄糖苷酶抑制率均在 30%至 40%之间。由 Lc.K782 发酵的骆驼乳具有最高的 2,2'-偶氮双（3-乙基苯并噻唑啉-6-磺酸）抗氧化活性。由 Lc.K782 发酵的骆驼乳 WSE 的血管紧张素转换酶抑制率最高>80%。当用发酵的骆驼乳提取物的 WSE 处理时，Caco-2、MCF-7 和 HELA 细胞的增殖受到更强烈的抑制。
