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Humoral immunity, the underestimated player in hepatitis B.

作者信息

Zhang Shuye, Zhao Juanjuan, Zhang Zheng

机构信息

Shanghai Public Health Clinical Center and Institute of Biomedical Sciences, Fudan University, 201508, Shanghai, China.

Research Center for Clinical & Translational Medicine, Beijing 302 Hospital, 100039, Beijing, China.

出版信息

Cell Mol Immunol. 2018 Jun;15(6):645-648. doi: 10.1038/cmi.2017.132. Epub 2017 Dec 11.

DOI:10.1038/cmi.2017.132
PMID:29225341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6078975/
Abstract
摘要

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本文引用的文献

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A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys.一种与人类FcRn结合力增强的新型治疗性抗乙肝病毒抗体可改善小鼠和猴子体内的药代动力学。
Protein Cell. 2018 Jan;9(1):130-134. doi: 10.1007/s13238-017-0438-y.
2
Antibody-mediated immunotherapy against chronic hepatitis B virus infection.抗慢性乙型肝炎病毒感染的抗体介导免疫疗法。
Hum Vaccin Immunother. 2017 Aug 3;13(8):1768-1773. doi: 10.1080/21645515.2017.1319021. Epub 2017 May 19.
3
Vaccines targeting preS1 domain overcome immune tolerance in hepatitis B virus carrier mice.靶向 preS1 结构域的疫苗可克服乙型肝炎病毒携带小鼠的免疫耐受。
Hepatology. 2017 Oct;66(4):1067-1082. doi: 10.1002/hep.29239. Epub 2017 Aug 26.
4
Exploring Human Antimicrobial Antibody Responses on a Single B Cell Level.在单个B细胞水平上探索人类抗菌抗体反应。
Clin Vaccine Immunol. 2017 May 5;24(5). doi: 10.1128/CVI.00544-16. Print 2017 May.
5
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.与免疫抑制及生物调节剂治疗相关的乙型肝炎再激活：当前概念、管理策略及未来方向
Gastroenterology. 2017 May;152(6):1297-1309. doi: 10.1053/j.gastro.2017.02.009. Epub 2017 Feb 20.
6
Use of Current and New Endpoints in the Evaluation of Experimental Hepatitis B Therapeutics.当前及新的终点指标在实验性乙型肝炎治疗药物评估中的应用
Clin Infect Dis. 2017 May 1;64(9):1283-1288. doi: 10.1093/cid/cix129.
7
Control of hepatitis B virus infection in hematopoietic stem cell recipients after receiving grafts from vaccinated donors.
Bone Marrow Transplant. 2016 Mar;51(3):428-31. doi: 10.1038/bmt.2015.253. Epub 2015 Oct 26.
8
Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen.新型抗体靶向乙肝表面抗原独特表位可在小鼠体内长期抑制 HBV。
Gut. 2016 Apr;65(4):658-71. doi: 10.1136/gutjnl-2014-308964. Epub 2015 Sep 30.
9
Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.B 细胞过度活化和功能受损的逆转与慢性乙型肝炎患者的 HBsAg 血清学转换相关。
Cell Mol Immunol. 2015 May;12(3):309-16. doi: 10.1038/cmi.2015.25. Epub 2015 Apr 6.
10
Re-evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells.通过系统生物学重新评估乙型肝炎病毒临床阶段，发现先天免疫反应和 B 细胞的作用未被充分认识。
Hepatology. 2015 Jul;62(1):87-100. doi: 10.1002/hep.27805. Epub 2015 Apr 27.