B10 细胞与成人症状性急性乙型肝炎感染期间的临床预后相关。
B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection.
机构信息
The Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
The First Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
出版信息
Front Immunol. 2022 Jun 13;13:906650. doi: 10.3389/fimmu.2022.906650. eCollection 2022.
There are few reports about the role of B10 cells in acute hepatitis B (AHB) infection. In this study, based on 48 acute hepatitis B infected patients, we analysis the correlation of B10 cells with HBV clinical prognosis. The results showed that B10 was positively correlated with HBsAg and HBeAg and inversely correlated with anti-HBs. The level of B10 in one week before HBsAg clearance was significantly lower than 2 weeks prior to HBsAg clearance and after 1-2 weeks of HBsAg clearance. B10 cell frequency displayed no correlation with HBV DNA; however, it showed significant temporal synchronization with hepatic inflammatory markers such as ALT. B10 level also associated with hospitalization time. These results indicated that B10 is closely related to the clinical prognosis of acute HBV infection.
关于 B10 细胞在急性乙型肝炎 (AHB) 感染中的作用鲜有报道。本研究基于 48 例急性乙型肝炎感染患者，分析了 B10 细胞与 HBV 临床预后的相关性。结果表明，B10 与 HBsAg 和 HBeAg 呈正相关，与抗-HBs 呈负相关。HBsAg 清除前一周的 B10 水平明显低于 HBsAg 清除前两周和 HBsAg 清除后 1-2 周。B10 细胞频率与 HBV DNA 无相关性，但与 ALT 等肝内炎症标志物呈显著的时间同步性。B10 水平也与住院时间有关。这些结果表明，B10 与急性 HBV 感染的临床预后密切相关。
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