吉西他滨和卡非佐米诱发的血栓性微血管病：依库珠单抗作为一种挽救生命的治疗方法
Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life-saving treatment.
作者信息
Gosain Rahul, Gill Amitoj, Fuqua Jacob, Volz Lesley H, Kessans Knable Mika R, Bycroft Ryan, Seger Sarah, Gosain Rohit, Rios Jorge A, Chao Ju-Hsien
机构信息
Division of Hematology and Medical Oncology James Graham Brown Cancer Center University of Louisville School of Medicine Louisville Kentucky.
Department of Medicine University of Louisville School of Medicine Louisville Kentucky.
出版信息
Clin Case Rep. 2017 Oct 9;5(12):1926-1930. doi: 10.1002/ccr3.1214. eCollection 2017 Dec.
Drug-induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro-inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemcitabine should be considered in the appropriate settings.
药物诱导的非典型溶血尿毒综合征（aHUS）很罕见；然而，早期诊断对于降低发病率和死亡率至关重要。确诊后，依库珠单抗似乎是抑制促炎反应激增的可行治疗选择。此外，在适当情况下应考虑卡非佐米和吉西他滨等药物的不良反应。
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