一名晚期成年神经母细胞瘤患者接受个性化药物治疗后出现了前所未有的存活情况，该患者为ALK阳性。
Hitherto unseen survival in an ALK-positive-patient with advanced stage adult ganglioneuroblastoma treated with personalized medicine.
作者信息
Risum Signe, Knigge Ulrich, Langer Seppo W
机构信息
Department of Oncology ENETS Neuroendocrine Tumor Centre of Excellence Rigshospitalet, Copenhagen University Hospital Copenhagen DK-2100 Denmark.
Department of Endocrinology ENETS Neuroendocrine Tumor Centre of Excellence Rigshospitalet, Copenhagen University Hospital Copenhagen DK-2100 Denmark.
出版信息
Clin Case Rep. 2017 Nov 7;5(12):2085-2087. doi: 10.1002/ccr3.1262. eCollection 2017 Dec.
Abstract
Survival of stage 4 ganglioneuroblastoma (GNB) patients is poor; no reports exist of patients surviving up to 5 years (1, 2). We report the clinical and therapeutic course of a patient with stage 4 GNB surviving beyond expectations due to a multimodal treatment approach incorporating new technologies in cancer diagnostic and treatment.
摘要
4期神经节神经母细胞瘤（GNB）患者的生存率很低；尚无患者存活达5年的报道（1, 2）。我们报告了1例4期GNB患者的临床和治疗过程，该患者因采用了融合癌症诊断和治疗新技术的多模式治疗方法，存活时间超出预期。
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2
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BMC Cancer. 2015 Nov 16;15:908. doi: 10.1186/s12885-015-1925-2.
3
Targeted therapies for treatment of non-small cell lung cancer--Recent advances and future perspectives.针对非小细胞肺癌的靶向治疗——最新进展与未来展望。
Int J Cancer. 2016 Jun 1;138(11):2549-61. doi: 10.1002/ijc.29915. Epub 2015 Dec 15.
4
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Surg Case Rep. 2015 Sep 11;1:79. doi: 10.1186/s40792-015-0062-0. eCollection 2015 Dec.
5
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6
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Pediatr Clin North Am. 2015 Feb;62(1):225-56. doi: 10.1016/j.pcl.2014.09.015.
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