Donna A, Crosignani P, Robutti F, Betta P G, Bocca R, Mariani N, Ferrario F, Fissi R, Berrino F
Department of Pathology, City Hospital-USSL, Alesandria, Italy.
Scand J Work Environ Health. 1989 Feb;15(1):47-53. doi: 10.5271/sjweh.1882.
The possible role of a class of herbicides, triazines, in ovarian carcinogenesis has been evaluated in a population-based case-referent study. The trade names reported by the study subjects, and the type of cultivation in which they worked, were used for the assessment of exposure. Women previously exposed to triazines showed a significant relative risk of 2.7 for ovarian neoplasms. Although none of the doses could be quantified for the study subjects, two risk trends in favor of the plausibility of the association were found: the first by duration and the second by probability of exposure. The population representativity of the study and the comparability of information between the cases and referents suggest the lack of any major bias in the results. Triazine-related risk remained consistent when the analysis was restricted to farmers and when the exposure to other herbicides and to other types of cultivation were considered. Unexposed farmers had the same risk as unexposed nonfarmers.
在一项基于人群的病例对照研究中，对一类除草剂——三嗪类化合物在卵巢癌发生过程中可能发挥的作用进行了评估。研究对象报告的商品名以及他们所从事的种植类型被用于评估暴露情况。既往接触过三嗪类化合物的女性患卵巢肿瘤的相对风险显著，为2.7。尽管无法对研究对象接触的剂量进行量化，但发现了两个有利于该关联合理性的风险趋势：第一个是按接触持续时间，第二个是按接触概率。该研究的人群代表性以及病例与对照之间信息的可比性表明结果不存在任何重大偏差。当分析仅限于农民，且考虑接触其他除草剂和其他种植类型时，与三嗪相关的风险仍然一致。未接触除草剂的农民与未接触除草剂的非农民风险相同。
