Inoue-Choi Maki, Weyer Peter J, Jones Rena R, Booth Benjamin J, Cantor Kenneth P, Robien Kim, Ward Mary H
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, USA.
Center for Health Effects of Environmental Contamination, University of Iowa, Iowa City, Iowa, USA.
Occup Environ Med. 2016 Sep;73(9):582-7. doi: 10.1136/oemed-2016-103575. Epub 2016 Jul 1.
Few studies have evaluated environmental chemical exposures in relation to ovarian cancer. We previously found an increased risk of ovarian cancer among postmenopausal women in Iowa associated with higher nitrate levels in public water supplies (PWS). However, elevated nitrate levels may reflect the presence of other agricultural chemicals, such as atrazine, one of the most commonly detected pesticides in Iowa PWS.
We evaluated the association between atrazine in drinking water and incident ovarian cancer (N=145, 1986-2010) among 13 041 postmenopausal women in the Iowa Women's Health Study who used their PWS for ≥11 years as reported in 1989. Average levels of atrazine (1986-1987), nitrate-nitrogen (NO3-N, 1955-1988) and estimated levels of total trihalomethanes (TTHM, 1955-1988) from PWS monitoring data were linked to the participants' cities of residence. We computed HRs and 95% CIs by categories of the average atrazine level (not detected, ≤ or >0.37 parts per billion=median) using Cox proportional hazards regression adjusting for ovarian cancer risk factors.
Atrazine was detected in water samples from 69 cities where 4155 women (32%) lived and levels were moderately correlated with NO3-N (ρ=0.35) and TTHM (ρ=0.24). Atrazine levels were not associated with ovarian cancer risk with or without adjusting for NO3-N and TTHM levels (p-trend=0.50 and 0.81, respectively). Further, there was no evidence for effect modification of the atrazine association by NO3-N or TTHM levels.
In our study with low atrazine detection rates, we found no association between atrazine in PWS and postmenopausal ovarian cancer risk.
很少有研究评估环境化学物质暴露与卵巢癌之间的关系。我们之前发现，爱荷华州绝经后女性中，公共供水系统（PWS）中硝酸盐水平较高与卵巢癌风险增加有关。然而，硝酸盐水平升高可能反映了其他农业化学品的存在，比如阿特拉津，它是爱荷华州公共供水系统中最常检测到的农药之一。
我们评估了1989年报告使用其公共供水系统≥11年的爱荷华州女性健康研究中13041名绝经后女性饮用水中阿特拉津与卵巢癌发病（1986 - 2010年，N = 145）之间的关联。根据公共供水系统监测数据得出的阿特拉津（1986 - 1987年）平均水平、硝酸盐氮（NO3 - N，1955 - 1988年）和总三卤甲烷估计水平（TTHM，1955 - 1988年）与参与者的居住城市相关联。我们使用Cox比例风险回归对卵巢癌风险因素进行调整，按阿特拉津平均水平类别（未检测到、≤或>十亿分之0.37 =中位数）计算风险比（HRs）和95%置信区间（CIs）。
在69个城市的水样中检测到了阿特拉津，4155名女性（32%）居住在这些城市，其水平与NO3 - N（ρ = 0.35）和TTHM（ρ = 0.24）呈中度相关。无论是否对NO3 - N和TTHM水平进行调整，阿特拉津水平与卵巢癌风险均无关联（p趋势分别为0.50和0.81）。此外，没有证据表明NO3 - N或TTHM水平对阿特拉津关联存在效应修正。
在我们阿特拉津检测率较低的研究中，我们发现公共供水系统中的阿特拉津与绝经后卵巢癌风险之间没有关联。
