Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan.
J Dermatol. 2018 Mar;45(3):252-263. doi: 10.1111/1346-8138.14112. Epub 2017 Dec 10.
Psoriasis is an inflammatory skin disorder that includes dynamic interactions between the immune system and skin and is clinically characterized by keratinocyte proliferation and distinct inflammatory cell infiltrates. Cross-talk between keratinocytes and immunocytes is essential for the development of psoriasis given that it mediates the production of cytokines, chemokines and growth factors. To resolve the pathogenesis of psoriasis, numerous experimental animal models have been generated. In this review, we discuss recent findings from mouse models, their relevancy to psoriasis and use, including the discovery of new therapies.
银屑病是一种炎症性皮肤疾病，包括免疫系统和皮肤之间的动态相互作用，其临床特征是角质形成细胞增殖和明显的炎症细胞浸润。鉴于角质形成细胞和免疫细胞之间的串扰介导细胞因子、趋化因子和生长因子的产生，对于银屑病的发病机制的研究至关重要。为了解决银屑病的发病机制，已经产生了许多实验动物模型。在这篇综述中，我们讨论了来自小鼠模型的最新发现，及其与银屑病的相关性和应用，包括新疗法的发现。
