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阿特卡玛宁 G-M,来自厚鳞柯茎部的prenylated 4-色满酮及其对酪氨酸酶的抑制活性。

Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities.

机构信息

Department of Chemistry, Graduate School of Science, Hiroshima University , Higashi-Hiroshima, Hiroshima 739-8526, Japan.

出版信息

J Nat Prod. 2017 Dec 22;80(12):3172-3178. doi: 10.1021/acs.jnatprod.7b00453. Epub 2017 Dec 11.

DOI:10.1021/acs.jnatprod.7b00453
PMID:29227656
Abstract

Phytochemical analysis of an EtOAc extract of the stems of Artocarpus rigida led to the identification of seven new prenylated 4-chromenones, artocarmins G-M (1-7), and nine known compounds (8-17). Their structures were identified based on physical data analysis. In the tyrosinase inhibitory activity test, norartocarpetin (8) displayed the strongest effect, with an IC value of 0.023 μM.

摘要

从 Artocarpus rigida 茎的 EtOAc 提取物的植物化学分析中,分离得到了 7 个新的prenylated 4-色满酮类化合物,即 artocarmins G-M(1-7),以及 9 个已知化合物(8-17)。它们的结构是根据物理数据分析确定的。在酪氨酸酶抑制活性测试中,norartocarpetin(8)表现出最强的效果,IC 值为 0.023 μM。

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