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从根部分离出的化合物的酪氨酸酶抑制特性

Tyrosinase Inhibitory Properties of Compounds Isolated from Roots.

作者信息

Siridechakorn Ittipon, Shinta Dina Nur, Ardiansah Ardiansah, Batsomboon Paratchata, Ngamrojanavanich Nattaya, Choodej Siwattra, Pudhom Khanitha

机构信息

Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road Laksi, Bangkok 10210, Thailand.

出版信息

J Nat Prod. 2024 Dec 27;87(12):2790-2800. doi: 10.1021/acs.jnatprod.4c00957. Epub 2024 Nov 18.

DOI:10.1021/acs.jnatprod.4c00957
PMID:39552474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11686508/
Abstract

A comprehensive phytochemical investigation of root extract led to the isolation of two new geranylated xanthones ( and ), one new geranylated flavone (), one new flavanone (), and one unique benzopyran (), along with 16 known compounds. Structures of the new compounds were elucidated by a combination of spectroscopic and computational methods. Two different types of compounds, flavone and arylbenzofuran , displayed the most potent antityrosinase activity with IC values of 1.7 ± 0.2 and 1.2 ± 0.1 μM, respectively. In addition, kinetic measurements and molecular docking simulations of compounds and were performed and revealed that compound is a competitive inhibitor binding with the tyrosinase active site, while compound is a noncompetitive tyrosinase inhibitor binding the enzyme at the allosteric site.

摘要

对根提取物进行全面的植物化学研究，分离出两种新的香叶基化氧杂蒽酮（和）、一种新的香叶基化黄酮（）、一种新的黄烷酮（）和一种独特的苯并吡喃（），以及16种已知化合物。通过光谱学和计算方法相结合阐明了新化合物的结构。两种不同类型的化合物，黄酮和芳基苯并呋喃，表现出最强的抗酪氨酸酶活性，IC值分别为1.7±0.2和1.2±0.1μM。此外，对化合物和进行了动力学测量和分子对接模拟，结果表明化合物是与酪氨酸酶活性位点结合的竞争性抑制剂，而化合物是在变构位点与该酶结合的非竞争性酪氨酸酶抑制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/cc5f66c1a0a0/np4c00957_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/0da46525e583/np4c00957_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/e2f0f6661d36/np4c00957_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/b2a4efce76fb/np4c00957_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/884de1943d44/np4c00957_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/cc5f66c1a0a0/np4c00957_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/0da46525e583/np4c00957_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/e2f0f6661d36/np4c00957_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/b2a4efce76fb/np4c00957_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/884de1943d44/np4c00957_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b8/11686508/cc5f66c1a0a0/np4c00957_0006.jpg

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