抗抑郁药戒断综合征：现象学与病理生理学

Antidepressant withdrawal syndromes: phenomenology and pathophysiology.

作者信息

Dilsaver S C

机构信息

Department of Psychiatry, Ohio State University, Columbus.

出版信息

Acta Psychiatr Scand. 1989 Feb;79(2):113-7. doi: 10.1111/j.1600-0447.1989.tb08578.x.

DOI:10.1111/j.1600-0447.1989.tb08578.x

PMID:2923004

Abstract

The literature reporting signs and symptoms produced by the abrupt or gradual withdrawal of antidepressants is reviewed. Patients with antidepressant withdrawal syndromes are presented and principles governing their care are highlighted. Finally, the author summarizes evidence that antidepressant-induced supersensitivity of central and peripheral muscarinic cholinergic mechanisms may account for commonly observed antidepressant withdrawal phenomena.

摘要

本文回顾了有关突然或逐渐停用抗抑郁药所产生的体征和症状的文献。介绍了患有抗抑郁药戒断综合征的患者，并强调了护理他们的原则。最后，作者总结了证据，表明抗抑郁药引起的中枢和外周毒蕈碱胆碱能机制超敏反应可能是常见的抗抑郁药戒断现象的原因。