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SEOM 临床指南：不明原发灶肿瘤（2017）

SEOM clinical guideline on unknown primary cancer (2017).

机构信息

Hospital de Sant Joan Despí Moisés Broggi, Sant Joan Despí, Barcelona, Spain.

Hospital Durán i Reynals (ICO-L'Hospitalet), Barcelona, Spain.

出版信息

Clin Transl Oncol. 2018 Jan;20(1):89-96. doi: 10.1007/s12094-017-1807-y. Epub 2017 Dec 11.

DOI:10.1007/s12094-017-1807-y
PMID:29230692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5785607/
Abstract

Cancer of unknown primary site is a histologically confirmed cancer that manifests in advanced stage, with no identifiable primary site following standard diagnostic procedures. Patients are initially categorized based on the findings of the initial biopsy: adenocarcinoma, squamous-cell carcinoma, neuroendocrine carcinoma, and poorly differentiated carcinoma. Appropriate patient management requires understanding several clinical and pathological features that aid in identifying several subsets of patients with more responsive tumors.

摘要

原发灶不明的癌症是一种组织学确诊的癌症，表现为晚期，经过标准诊断程序后仍无法确定原发灶。患者最初根据初始活检的结果进行分类：腺癌、鳞状细胞癌、神经内分泌癌和低分化癌。适当的患者管理需要了解几个临床和病理特征，这些特征有助于确定具有更敏感肿瘤的几个亚组患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b34/5785607/83287a0e1ede/12094_2017_1807_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b34/5785607/83287a0e1ede/12094_2017_1807_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b34/5785607/83287a0e1ede/12094_2017_1807_Fig1_HTML.jpg

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Arch Pathol Lab Med. 2017 Jan;141(1):144-150. doi: 10.5858/arpa.2015-0404-OA.
2
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.基于表观遗传学特征对不明原发灶癌进行分类：一项多中心、回顾性分析。
Lancet Oncol. 2016 Oct;17(10):1386-1395. doi: 10.1016/S1470-2045(16)30297-2. Epub 2016 Aug 27.
3
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4
Exceptional response to immunotherapy monotherapy in a patient with an unfavorable subset of cancer of unknown primary.一名原发性不明癌症预后不良亚组患者对免疫治疗单药治疗反应显著。
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5
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ESMO Open. 2023 Dec;8(6):102035. doi: 10.1016/j.esmoop.2023.102035. Epub 2023 Nov 2.
6
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