18F-氟代脱氧葡萄糖正电子发射断层扫描-计算机断层扫描作为不明原发灶颈部淋巴结转移患者的诊断工具：一项荟萃分析。
18F-fluorodeoxyglucose positron emission tomography-computed tomography as a diagnostic tool in patients with cervical nodal metastases of unknown primary site: a meta-analysis.
机构信息
Department of Otolaryngology & Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Gongti Nanlu No.8, Chaoyang District, Beijing 100020, PR China.
出版信息
Surg Oncol. 2013 Sep;22(3):190-4. doi: 10.1016/j.suronc.2013.06.002. Epub 2013 Jul 11.
BACKGROUND
We performed a meta-analysis to evaluate the value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography ((18)FDG PET-CT) for the detection of primary sites in patients with cervical nodal metastases of unknown origin.
METHODS
Studies were systematically searched for relevant PET-CT original articles in the MEDLINE and EMBASE databases. We calculated the primary tumor detection rate, sensitivity, specificity, and likelihood ratios for (18)FDG PET-CT. We also constructed the hierarchic summary receiver operating characteristic curve for (18)FDG PET-CT.
RESULTS
This present study analyzed a total of 7 selected studies (246 patients). The primary tumor detection rate, sensitivity and specificity of PET-CT were 0.44 (95% confidence interval [CI] = 0.31-0.58), 0.97 (95% CI = 0.63-0.99), and 0.68 (95% CI = 0.49-0.83). Area under the curve was 0.83 (95% CI = 0.80-0.86).
CONCLUSIONS
(18)FDG PET-CT has high sensitivity and low specificity for the detection of primary sites in patients with cervical nodal metastases of unknown origin.
背景
我们进行了一项荟萃分析，以评估（18）氟-脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（（18）FDG PET-CT）在检测不明来源的颈部淋巴结转移患者原发灶中的价值。
方法
系统地在 MEDLINE 和 EMBASE 数据库中搜索相关的 PET-CT 原始文章。我们计算了（18）FDG PET-CT 的原发肿瘤检出率、敏感度、特异度和似然比。我们还构建了（18）FDG PET-CT 的分层汇总受试者工作特征曲线。
结果
本研究共分析了 7 项选定的研究（246 例患者）。PET-CT 的原发肿瘤检出率、敏感度和特异度分别为 0.44（95%置信区间 [CI] = 0.31-0.58）、0.97（95% CI = 0.63-0.99）和 0.68（95% CI = 0.49-0.83）。曲线下面积为 0.83（95% CI = 0.80-0.86）。
结论
（18）FDG PET-CT 对检测不明来源的颈部淋巴结转移患者的原发灶具有较高的敏感度和较低的特异度。
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