Cunningham J J, Hegarty M T, Meara P A, Burke J F
Pediatric Endocrine Unit, Shriners Burns Institute, Children's Service, Boston, MA 02114.
Am J Clin Nutr. 1989 Mar;49(3):404-8. doi: 10.1093/ajcn/49.3.404.
Major burn trauma produces large elevations in metabolic energy expenditure (MEE) during acute care. However, overfeeding can occur and is detrimental to recovery. The formulae often used to estimate caloric support to meet MEE are based on body weight, predicted resting metabolic rate (RMR), body surface area, or the total body surface area burned (BSAB). These predictive equations originate from studies of less than or equal to 30 patients generally lacking measurements beyond the third week of convalescence. We report 565 measurements by indirect calorimetry for 122 adults between the burn day and day 149 postburn. A standardized protocol of nutritional support and early wound closure was followed. Predictions of MEE are compared in subcategories of BSAB (2-25%; 30-50%; 51-75%; and 76-98%). For major burns exceeding 30% BSAB, 2X the predicted RMR was consistently closest to the measured MEE, assuring adequate calorie provision while minimizing the risk of overfeeding.
严重烧伤创伤在急性护理期间会导致代谢能量消耗(MEE)大幅升高。然而,可能会出现过度喂养的情况,这对恢复不利。常用于估算满足MEE所需热量支持的公式是基于体重、预测静息代谢率(RMR)、体表面积或烧伤总面积(BSAB)。这些预测方程源自对一般不超过30名患者的研究,通常缺乏康复第三周之后的测量数据。我们报告了122名成年人在烧伤当天至烧伤后第149天期间通过间接测热法进行的565次测量。遵循了标准化的营养支持和早期伤口闭合方案。在BSAB的子类别(2 - 25%;30 - 50%;51 - 75%;和76 - 98%)中比较了MEE的预测值。对于超过30% BSAB的大面积烧伤,预测RMR的2倍始终最接近测量的MEE,既能确保充足的热量供应,又能将过度喂养的风险降至最低。