硅基烯酮缩醛与α,β-不饱和甲酯的不对称 Mukaiyama-Michael 反应的催化作用。
The Catalytic Asymmetric Mukaiyama-Michael Reaction of Silyl Ketene Acetals with α,β-Unsaturated Methyl Esters.
机构信息
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
出版信息
Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2464-2468. doi: 10.1002/anie.201712088. Epub 2018 Jan 26.
PMID:29232022
Abstract
α,β-Unsaturated esters are readily available but challenging substrates to activate in asymmetric catalysis. We now describe an efficient, general, and highly enantioselective Mukaiyama-Michael reaction of silyl ketene acetals with α,β-unsaturated methyl esters that is catalyzed by a silylium imidodiphosphorimidate (IDPi) Lewis acid.
摘要
α,β-不饱和酯是容易获得的，但在不对称催化中难以激活的底物。我们现在描述了一种高效、通用且高度对映选择性的硅基烯酮缩醛与α,β-不饱和甲酯的 Mukaiyama-Michael 反应，该反应由硅鎓亚胺二膦酰亚胺（IDPi）路易斯酸催化。
Zotero 插件