Finding a Silver Bullet in a Stack of Proteins.
作者信息
Makhlynets Olga V, Korendovych Ivan V
机构信息
Department of Chemistry, Syracuse University , 111 College Place, Syracuse, New York 13244, United States.
出版信息
Biochemistry. 2017 Dec 26;56(51):6627-6628. doi: 10.1021/acs.biochem.7b01177. Epub 2017 Dec 12.
Abstract
摘要
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Nature. 2017 Oct 5;550(7674):74-79. doi: 10.1038/nature23912. Epub 2017 Sep 27.
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Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.小分子，大目标：药物发现面临蛋白-蛋白相互作用挑战。
Nat Rev Drug Discov. 2016 Aug;15(8):533-50. doi: 10.1038/nrd.2016.29. Epub 2016 Apr 11.
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Proteins from an unevolved library of de novo designed sequences bind a range of small molecules.来自从头设计序列的未进化文库的蛋白质能结合一系列小分子。
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BMC Biochem. 2011 Nov 15;12:58. doi: 10.1186/1471-2091-12-58.
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