College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University , Fuzhou 350108, China.
Department of Chemistry and Nano Science, Ewha Womans University , Seoul 120-750, South Korea.
ACS Nano. 2018 Jan 23;12(1):681-688. doi: 10.1021/acsnano.7b07809. Epub 2017 Dec 22.
Supramolecular chemistry provides a "bottom-up" method to fabricate nanostructures for biomedical applications. Herein, we report a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission and singlet oxygen generation associated with the formation of free PcS, mild photothermal heating, and a concomitant chemotherapeutic effect associated with the formation of free MA. In vivo evaluations indicate that PcS-MA nanostructures have a high level of accumulation in tumor tissues, are capable of being used for cancer imaging, and have significantly improved anticancer effect compared to that of PcS. This study demonstrates an attractive strategy for overcoming the limitations of photodynamic cancer therapy.
超分子化学为生物医学应用提供了一种“自下而上”的方法来制造纳米结构。在此，我们报告了一种简便的策略，可直接将卟啉类光敏剂（PcS）与抗癌药物米托蒽醌（MA）组装形成均匀的纳米结构（PcS-MA），其不仅具有纳米级光学性质，而且还具有经历核酸响应性解体的能力。这些超分子组装体具有与游离 PcS 的形成相关的可激活的荧光发射和单线态氧生成、温和的光热加热以及与游离 MA 的形成相关的伴随的化学治疗效果。体内评估表明，PcS-MA 纳米结构在肿瘤组织中有高水平的积累，可用于癌症成像，并与 PcS 相比具有显著提高的抗癌效果。本研究为克服光动力癌症治疗的局限性提供了一种有吸引力的策略。
