妊娠肝内胆汁淤积症患者中新型肝因子胎球蛋白B水平升高。
Increased levels of the novel hepatokine fetuin B in patients with intrahepatic cholestasis of pregnancy.
作者信息
Koroglu Nadiye, Tayyar Ahmet, Tola Esra Nur, Yetkin Yildirim Gonca, Temel Yuksel Ilkbal, Aslan Cetin Berna, Dag Ismail, Acar Deniz Kanber
机构信息
a Department of Obstetrics and Gynecology , Istanbul Health Sciences University Kanuni Sultan Suleyman Training and Research Hospital , Istanbul , Turkey.
b Maternal-Fetal Medicine Unit, Istanbul Health Sciences University Kanuni Sultan Suleyman Training and Research Hospital , Istanbul , Turkey.
出版信息
J Matern Fetal Neonatal Med. 2019 May;32(10):1620-1625. doi: 10.1080/14767058.2017.1413546. Epub 2017 Dec 12.
OBJECTIVES
To investigate liver-derived plasma protein fetuin B levels in healthy pregnant women and pregnant women with intrahepatic cholestasis of pregnancy (ICP).
MATERIALS AND METHODS
Forty women with ICP and 40 healthy pregnant women were included in this cross-sectional study. The serum fetuin B levels of these patients were analyzed. The patients were followed up to delivery.
RESULTS
Maternal age, gravida, parity, BMI at assessment, and gestational age at blood sampling were similar between the ICP and control groups (p > .05). However, the gestational age at delivery and the birth weight were significantly lower in the ICP group (p < .05). Total bile acid (TBA) levels and liver function tests were significantly higher in the ICP group than in the control group (p < .0001 and < .0001, respectively). In addition, serum fetuin B concentrations were significantly higher in the ICP group than in the control group (p < .0001). The best cutoff for fetuin B serum concentration was 5540.2 pg/mL. Serum values greater than this threshold had 80% sensitivity and 65% specificity for the diagnosis of ICP.
CONCLUSIONS
Serum fetuin B was higher in patients with ICP compared to healthy pregnant women and might be a new biomarker.
目的
研究健康孕妇和妊娠肝内胆汁淤积症（ICP）孕妇肝脏来源的血浆蛋白胎球蛋白B水平。
材料与方法
本横断面研究纳入了40例ICP孕妇和40例健康孕妇。分析了这些患者的血清胎球蛋白B水平。对患者进行随访至分娩。
结果
ICP组和对照组之间的产妇年龄、孕次、产次、评估时的BMI以及采血时的孕周相似（p＞0.05）。然而，ICP组的分娩孕周和出生体重显著更低（p＜0.05）。ICP组的总胆汁酸（TBA）水平和肝功能检查显著高于对照组（分别为p＜0.0001和＜0.0001）。此外，ICP组的血清胎球蛋白B浓度显著高于对照组（p＜0.0001）。胎球蛋白B血清浓度的最佳截断值为5540.2 pg/mL。血清值高于此阈值对ICP诊断的敏感性为80%，特异性为65%。
结论
与健康孕妇相比，ICP患者的血清胎球蛋白B更高，可能是一种新的生物标志物。
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