Chen Zhong, Shen Zongji, Hu Lingqing, Lu Mudan, Feng Yizhong
Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.
Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ann Hepatol. 2017 March-April;16(2):291-296. doi: 10.5604/16652681.1231589.
Intrahepatic cholestasis of pregnancy (ICP) is a severe liver disease uniquely occurring during pregnancy. In this study we aimed to identify novel biomarker for the diagnosis of ICP in Chinese population. 50 healthy pregnant women, 50 mild ICP patients and 48 severe ICP patients were enrolled for this study. Liver function tests, including serum total bilirubin, direct bilirubin, alanine transaminase, aspartate aminotransferase and cholyglycine, were performed in all participants. After an overnight fast serum levels of total bile acids (TBA), matrix metalloproteinase (MMP)-2 and MMP-9 were measured, and their correlation with liver function tests were analyzed. The observed increase in serum TBA in ICP patients was not statistically significant which made it unreliable for diagnosis of ICP in Chinese population. On the other hand, both MMP-2 and MMP-9 serum levels exhibited a progressive and significant elevation in mild and severe ICP patients compared with healthy pregnant women, which also positively correlated with liver function tests. Serum levels of both MMP-2 and MMP-9 could be reliably used as laboratory abnormalities for accurate diagnosis and sensitive grading of ICP in Chinese population.
妊娠期肝内胆汁淤积症（ICP）是一种仅在孕期发生的严重肝脏疾病。在本研究中，我们旨在识别用于诊断中国人群ICP的新型生物标志物。本研究纳入了50名健康孕妇、50名轻度ICP患者和48名重度ICP患者。对所有参与者进行了肝功能检查，包括血清总胆红素、直接胆红素、丙氨酸转氨酶、天冬氨酸转氨酶和胆甘氨酸。在空腹过夜后，测量血清总胆汁酸（TBA）、基质金属蛋白酶（MMP）-2和MMP-9水平，并分析它们与肝功能检查结果的相关性。观察到ICP患者血清TBA升高无统计学意义，这使其在中国人群中用于诊断ICP不可靠。另一方面，与健康孕妇相比，轻度和重度ICP患者的血清MMP-2和MMP-9水平均呈进行性显著升高，且与肝功能检查结果呈正相关。血清MMP-2和MMP-9水平均可可靠地用作实验室异常指标，用于中国人群ICP的准确诊断和敏感分级。
