Tayyar Ahter Tanay, Tayyar Ahmet, Kozali Sukran, Karakus Resul, Koroglu Nadiye, Yuksel Ilkbal Temel, Yildirim Gonca Yetkin, Dag Ismail, Eroglu Mustafa
Department of Obstetrics and Gynecology, Health Sciences University Zeynep Kamil Maternity and Children's Research Hospital, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Health Sciences University Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
Arch Med Sci. 2019 Jan;15(1):113-119. doi: 10.5114/aoms.2017.72424. Epub 2018 Jan 10.
Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism. In this study, our aim was to investigate the circulating FGF-19 and β-klotho levels in intrahepatic cholestasis of pregnancy (ICP) cases.
A cross-sectional study including 40 women whose pregnancies were complicated with ICP were recruited for the study group. Forty randomly selected healthy pregnant women comprised the control group. The patient characteristics, including maternal age, gravidity, parity, gestational age at the time of diagnosis, body mass index (BMI), and obstetric history, were recorded. The serum FGF-19 and β-klotho concentrations were measured using an enzyme-linked immunosorbent assay.
Maternal age, gravidity, parity, body mass index at assessment, and gestational age at blood sampling were similar between the two groups ( > 0.05). Moreover, there were no significant differences in the FGF-19 and β-klotho concentrations between the two groups ( = 0.341 and = 0.086, respectively). A positive correlation was detected between the β-klotho and FGF-19 levels, as well as between the FGF-19 level and BMI ( = 0.368, = 0.020 and = 0.389, = 0.013, respectively).
The serum FGF-19 and β-klotho concentrations did not differ between the pregnancies with ICP and the healthy controls. However, in some cases, abnormalities in the FGF-19, β-klotho, and FGFR4 signaling system may play roles in the pathogenesis of ICP.
成纤维细胞生长因子19（FGF-19）及其共受体β-klotho作为一种肠肝循环反馈机制调节肝脏中的胆汁酸合成。在本研究中，我们的目的是调查妊娠肝内胆汁淤积症（ICP）患者的循环FGF-19和β-klotho水平。
一项横断面研究纳入了40例妊娠合并ICP的女性作为研究组。40例随机选取的健康孕妇组成对照组。记录患者特征，包括产妇年龄、孕次、产次、诊断时的孕周、体重指数（BMI）和产科病史。采用酶联免疫吸附测定法测量血清FGF-19和β-klotho浓度。
两组间产妇年龄、孕次、产次、评估时的体重指数和采血时的孕周相似（P>0.05）。此外，两组间FGF-19和β-klotho浓度无显著差异（分别为P = 0.341和P = 0.086）。检测到β-klotho与FGF-19水平之间以及FGF-19水平与BMI之间呈正相关（分别为r = 0.368，P = 0.020和r = 0.389，P = 0.013）。
ICP妊娠患者与健康对照组的血清FGF-19和β-klotho浓度无差异。然而，在某些情况下，FGF-19、β-klotho和FGFR4信号系统的异常可能在ICP的发病机制中起作用。
