a MRC Toxicology Unit , Hodgkin Building , Lancaster Road, Leicester LE1 9HN , United Kingdom.
b Department of Experimental Medicine and Surgery , University of Rome Tor Vergata , Rome 00133 , Italy.
Cell Cycle. 2018;17(5):589-594. doi: 10.1080/15384101.2017.1403684. Epub 2018 Feb 8.
As a member of p53 family, p73 has attracted intense investigations due to its structural and functional similarities to p53. Among more than ten p73 variants, the transactivation (TA) domain-containing isoform TAp73 is the one that imitates the p53's behavior most. TAp73 induces apoptosis and cell cycle arrest, which endows it the capacity of tumour suppression. Also, it can exert diverse biological influences on cells through activating a complex and context dependent transcriptional programme. The transcriptional activities further broaden its roles in more intricate biological processes. In this article, we report that p73 is a positive regulator of a cell adhesion related gene named integrin β4 (ITGB4). This finding may have implications for the dissection of the biological mechanisms underlining p73 functions.
作为 p53 家族的一员，p73 因其与 p53 的结构和功能相似而引起了强烈的研究兴趣。在十多种 p73 变体中，含有转录激活（TA）结构域的同型异构体 TAp73 最能模仿 p53 的行为。TAp73 诱导细胞凋亡和细胞周期停滞，从而赋予其肿瘤抑制能力。此外，它还可以通过激活复杂且依赖上下文的转录程序，对细胞产生不同的生物学影响。这些转录活性进一步扩展了它在更复杂的生物学过程中的作用。在本文中，我们报告 p73 是一个细胞黏附相关基因整合素β4（ITGB4）的正调控因子。这一发现可能对解析 p73 功能的生物学机制具有重要意义。
