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在低危妊娠中，18 至 24 孕周胎儿鼻骨长度、鼻前厚度和眼距的参考范围。

Reference ranges for foetal nasal bone length, prenasal thickness, and interocular distance at 18 to 24 weeks' gestation in low-risk pregnancies.

机构信息

Department of Radiology, Konya Education and Research Hospital, Health Sciences University, Konya, Turkey.

Radyoloji Bölümü Hacı Şaban Mah, Sağlık Bilimleri Üniversitesi, Konya Eğitim ve Araştırma Hastanesi, Meram Yeni Yol Caddesi, No: 97, PK, Meram, Konya, 42090, Turkey.

出版信息

BMC Pregnancy Childbirth. 2017 Dec 12;17(1):416. doi: 10.1186/s12884-017-1602-3.

DOI:10.1186/s12884-017-1602-3
PMID:29233116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5727986/
Abstract

BACKGROUND

The aim of the present study was to establish the normal ranges for foetal nasal bone length (NBL), prenasal skin thickness (PNT), interocular distance (IOD), and ratio of prenasal thickness to- nasal bone length (PNT/ NBL) at 18-24 weeks using two-dimensional (2D) ultrasound.

METHODS

This study was a retrospective study of prenatal ultrasonographic records from 407 foetuses between 18 and 24 weeks gestational age (GA). The NBL, PNT, IOD, PNT/ NBL ratio, biparietal diameter (BPD), and femur length (FL) were investigated. The relationships among NBL, PNT, IOD, PNT/ NBL, and GA were evaluated. Additionally, descriptive statistics for NBL, PNT, and IOD values for each gestational week were obtained.

RESULTS

There was a significant association between GA and NBL, PNT, and IOD between 18 and 24 weeks. NBL increased from a mean of 5.5 mm to 8.3 mm, PNT increased from a mean of 3.5 mm to 5.1 mm, and IOD increased from a mean of 11.1 mm to 14.5 mm. PNT/NBL ratio did not change with gestational age.

CONCLUSIONS

This study showed normal ranges for NBL, PNT, IOD, and PNT/ NBL ratios for foetuses between 18 and 24 weeks in low-risk pregnancies. There was a positive linear relationship between GA and NBL, PNT, and IOD. The PNT/NBL ratio might be a more useful measurement than NBL or PNT alone.

摘要

背景

本研究旨在通过二维（2D）超声建立 18-24 孕周胎儿鼻骨长度（NBL）、鼻前皮肤厚度（PNT）、眼距（IOD）和鼻前厚度与鼻骨长度比（PNT/NBL）的正常范围。

方法

这是一项回顾性研究，纳入了 407 例 18-24 孕周胎儿的产前超声记录。研究了 NBL、PNT、IOD、PNT/NBL 比值、双顶径（BPD）和股骨长（FL）。评估了 NBL、PNT、IOD 与 GA 之间的关系。此外，还获得了每个孕周 NBL、PNT 和 IOD 值的描述性统计数据。

结果

18-24 周时，GA 与 NBL、PNT 和 IOD 之间存在显著相关性。NBL 从平均 5.5mm 增加到 8.3mm，PNT 从平均 3.5mm 增加到 5.1mm，IOD 从平均 11.1mm 增加到 14.5mm。PNT/NBL 比值与胎龄无关。

结论

本研究显示了低危妊娠 18-24 周胎儿 NBL、PNT、IOD 和 PNT/NBL 比值的正常范围。GA 与 NBL、PNT 和 IOD 之间存在正线性关系。PNT/NBL 比值可能比 NBL 或 PNT 更有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8503/5727986/5cc6c9ffffb3/12884_2017_1602_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8503/5727986/98bc0aa16b90/12884_2017_1602_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8503/5727986/5cc6c9ffffb3/12884_2017_1602_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8503/5727986/98bc0aa16b90/12884_2017_1602_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8503/5727986/5cc6c9ffffb3/12884_2017_1602_Fig2_HTML.jpg

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Nasal bone length: prenasal thickness ratio: a strong 2D ultrasound marker for Down syndrome.鼻骨长度与鼻前厚度比值：唐氏综合征的一种强大二维超声标志物。
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Frontonasal fold thickness-to-nasal bone length ratio as a prenatal sonographic marker for trisomy 21 in a low-risk population.
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