Cronin William A, Hall Aaron A, Auker Charles R, Mahon Richard T
Aerosp Med Hum Perform. 2018 Jan 1;89(1):14-18. doi: 10.3357/AMHP.4925.2018.
Perfluorocarbons (PFC) are fluorinated hydrocarbons that dissolve gases to a much greater degree than plasma and hold promise in treating decompression sickness (DCS). The efficacy of PFC in a mixed gender model of DCS and safety in recompression therapy has not been previously explored.
Swine (25 kg; N = 104; 51 male and 53 female) were randomized into normal saline solution (NSS) or PFC emulsion treatment groups and subjected to compression on air in a hyperbaric chamber at 200 fsw for 31 min. Then the animals were decompressed and observed for signs of DCS. Afterwards, they were treated with oxygen and either PFC (4 cc · kg-1) or NSS (4 cc · kg-1). Surviving animals were observed for 4 h, at which time they underwent recompression therapy using a standard Navy Treatment Table 6. After 24 h the animals were assessed and then euthanized.
Survival rates were not significantly different between NSS (74.04%) and PFC (66.67%) treatment groups. All swine that received recompression treatment survived to the end of the study and no seizures were observed in either PFC or NSS animals. Within the saline treated swine group there were no significant differences in DCS survival between male (75.00%, N = 24) and female (73.08%, N = 26) swine. Within the PFC treated swine, survival of females (51.85%, N = 27) was significantly lower than males (81.48%, N = 27).
In this large animal mixed gender efficacy study in DCS, PFC did not improve mortality or spinal cord injury, but appears safe during recompressive therapy. Gender differences in DCS treatment with PFC will need further study.Cronin WA, Hall AA, Auker CR, Mahon RT. Perfluorocarbon in delayed recompression with a mixed gender swine model of decompression sickness. Aerosp Med Hum Perform. 2018; 89(1):14-18.
全氟化碳（PFC）是氟化烃，其溶解气体的程度比血浆大得多，有望用于治疗减压病（DCS）。此前尚未探讨过PFC在DCS混合性别模型中的疗效以及再压缩治疗中的安全性。
将猪（25千克；N = 104；51只雄性和53只雌性）随机分为生理盐水溶液（NSS）或PFC乳剂治疗组，并在高压舱内以200英尺海水深度（fsw）的空气进行31分钟的加压。然后对动物进行减压，并观察DCS的体征。之后，用氧气和PFC（4毫升·千克-1）或NSS（4毫升·千克-1）对它们进行治疗。对存活的动物观察4小时，此时它们使用标准的海军治疗表6进行再压缩治疗。24小时后对动物进行评估，然后实施安乐死。
NSS治疗组（74.04%）和PFC治疗组（66.67%）的存活率无显著差异。所有接受再压缩治疗的猪都存活到了研究结束，且在PFC或NSS处理的动物中均未观察到癫痫发作。在生理盐水处理的猪组中，雄性猪（75.00%，N = 24）和雌性猪（73.08%，N = 26）的DCS存活率无显著差异。在PFC处理的猪中, 雌性猪的存活率（51.85%，N = 27）显著低于雄性猪（81.48%，N = 27）。
在这项关于DCS的大型动物混合性别疗效研究中，PFC并未提高死亡率或脊髓损伤率，但在再压缩治疗期间似乎是安全的。PFC治疗DCS的性别差异需要进一步研究。克罗宁WA，霍尔AA，奥克CR，马洪RT。全氟化碳在减压病混合性别猪模型的延迟再压缩中的应用。航空航天医学与人类表现。2018；89(1):14 - 18。
