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[法国妇产科医生对无创产前检测的看法与实践概述]

[Overview of feelings and practices of gynecologists and obstetricians for the noninvasive prenatal testing in France].

作者信息

Bardy-Evrard C, Mattuizzi A, Coatleven F, Nithart A, Evrard G, Benachi A, Nisand I, Sentilhes L

机构信息

Service de gynécologie-obstétrique, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.

Service de gynécologie-obstétrique, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.

出版信息

Gynecol Obstet Fertil Senol. 2018 Jan;46(1):34-40. doi: 10.1016/j.gofs.2017.11.002. Epub 2017 Dec 7.

DOI:10.1016/j.gofs.2017.11.002
PMID:29233528
Abstract

OBJECTIVES

To evaluate the feelings and practices of French obstetrician-gynecologists in prescribing the noninvasive prenatal testing (NIPT) before the release of the French High Authority of Health recommendations.

METHODS

Descriptive, declarative and transversal study, analyzing the feelings and practices of obstetrician-gynecologists, members of the French College of Gynecologists and Obstetricians (CNGOF) between February and May 2017 using an online questionnaire. Practitioners' feedback was self-assessed for several clinical situations using a numerical scale ranging from 1 to 10. This experience was rated as "good" (grades 6 to 10) or "bad" (grades 1-5).

RESULTS

Overall, 529 practitioners (29.2%) of 1812 CNGOF members, answered the online questionnaire. A "good" feeling was found for more than 65% of the practitioners audited. Feelings were significantly better for obstetricians, sonographers (P<0.05) and CPDPN members (P=0.003) compared to other practitioners. Situations where the DPNI was proposed "systematically" were risks greater than 1/250 (70.9%), between 1/250 and 1/500 (59.4%), greater than 1/250 associated with history of spontaneous miscarriages and/or fetal death in utero (66%), greater than 1/250 associated with pregnancy resulting from PMA (68.3%), history of fetal aneuploidy (54%) and a parent carrying a Robertsonian translocation (51.6%).

CONCLUSION

This study highlights a good overall feeling of the practitioners with the NIPT.

摘要

目的

在法国卫生高级管理局发布相关建议之前,评估法国妇产科医生在开具无创产前检测(NIPT)时的感受和做法。

方法

描述性、陈述性和横断面研究,于2017年2月至5月使用在线问卷分析法国妇产科医师学会(CNGOF)成员中妇产科医生的感受和做法。从业者对几种临床情况的反馈采用1至10的数字量表进行自我评估。这种体验被评为“良好”(6至10分)或“不佳”(1至5分)。

结果

总体而言,1812名CNGOF成员中的529名从业者(29.2%)回答了在线问卷。超过65%接受调查的从业者感觉“良好”。与其他从业者相比,产科医生、超声检查医师(P<0.05)和CPDPN成员(P=0.003)的感受明显更好。“系统性”提出NIPT的情况包括风险大于1/250(70.9%)、1/250至1/500之间(59.4%)、大于1/250且伴有自然流产史和/或宫内胎儿死亡史(66%)、大于1/250且与辅助生殖技术妊娠相关(68.3%)、胎儿非整倍体病史(54%)以及父母一方携带罗伯逊易位(51.6%)。

结论

本研究突出了从业者对NIPT总体感觉良好。

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