Cheng Melodyanne Y, Chea Piseth Dalin, Latifi Golshan, Garner Omai B, Deng Sophie X, Fung Simon S M
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Department of Ophthalmology, University of California Los Angeles, Los Angeles, CA.
Cornea. 2024 Dec 10;44(9):1113-1118. doi: 10.1097/ICO.0000000000003770.
The purpose of this study was to assess trends in microbiology profiles and antibiotic susceptibility among pediatric infectious keratitis cases in Southern California, United States.
This is a retrospective chart review of patients aged 18 years or younger diagnosed with infectious keratitis with a positive microbiology culture between 2006 and 2019 at a tertiary academic institution. Patient demographics, microbiology results, and antibiotic susceptibilities were analyzed.
There were 23 patients included in the study period. The mean age (±SD) was 11 ± 7 years, with 60% 10 years and older. 75% were female, and 45% were of Hispanic or Latino descent. A total of 14 patients (61%) presented between June and November. A total of 30 microorganisms were identified from 24 corneal cultures of 23 eyes, and 92% were bacterial. The most common gram-positive and gram-negative isolates were Staphylococcus spp. (5/13, 38%) and Pseudomonas spp. (9/15, 60%), respectively. 92.3% gram-positive isolates were susceptible to vancomycin, but only 7.7% were susceptible to erythromycin. Gram-negative isolates were susceptible to gentamicin (86%), ciprofloxacin (79%), and ceftazidime (55%). Pseudomonas spp. was highly susceptible to gentamicin (100%) and ciprofloxacin (83%), and it was moderately susceptible to tobramycin (44%) and ceftazidime (67%).
Pediatric microbial keratitis cases in Southern California were predominantly bacterial infections, with gram-positive isolates highly susceptible to vancomycin and gram-negative isolates, particularly Pseudomonas spp., showing high susceptibility to gentamicin and ciprofloxacin.
本研究旨在评估美国南加州儿童感染性角膜炎病例的微生物学特征及抗生素敏感性趋势。
这是一项对2006年至2019年期间在一所三级学术机构被诊断为感染性角膜炎且微生物培养呈阳性的18岁及以下患者的回顾性病历审查。分析了患者的人口统计学特征、微生物学结果和抗生素敏感性。
研究期间共纳入23例患者。平均年龄（±标准差）为11±7岁，其中60%为10岁及以上。75%为女性，45%为西班牙裔或拉丁裔。共有14例患者（61%）在6月至11月期间就诊。从23只眼睛的24份角膜培养物中总共鉴定出30种微生物，其中92%为细菌。最常见的革兰氏阳性菌和革兰氏阴性菌分离株分别为葡萄球菌属（5/13，38%）和假单胞菌属（9/15，60%）。92.3%的革兰氏阳性菌分离株对万古霉素敏感，但仅7.7%对红霉素敏感。革兰氏阴性菌分离株对庆大霉素（86%）、环丙沙星（79%）和头孢他啶（55%）敏感。假单胞菌属对庆大霉素（100%）和环丙沙星（83%）高度敏感，对妥布霉素（44%）和头孢他啶（67%）中度敏感。
南加州儿童微生物性角膜炎病例主要为细菌感染，革兰氏阳性菌分离株对万古霉素高度敏感，革兰氏阴性菌分离株，尤其是假单胞菌属，对庆大霉素和环丙沙星高度敏感。
