Gu Shoujun, Nguyen Bao-Ngoc, Rao Shuyun, Li Shulin, Shetty Kirti, Rashid Asif, Shukla Vivek, Deng Chu-Xia, Mishra Lopa, Mishra Bibhuti
Department of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA.
Departments of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Genes Cancer. 2017 Sep;8(9-10):695-700. doi: 10.18632/genesandcancer.156.
Dosage, gender, and genetic susceptibility to the effects of alcohol remained only partially elucidated. In this review, we summarize the current knowledge of the mechanisms underlying the role of alcohol in liver and gastrointestinal cancers. In addition, two recent pathways- DNA repair and TGF-β signaling which provide new insights into alcohol in the regulation of cancers and stem cells are also discussed here.
酒精的剂量、性别以及对其影响的遗传易感性仍只是部分得到阐明。在本综述中，我们总结了目前关于酒精在肝癌和胃肠道癌中作用的潜在机制的知识。此外，本文还讨论了最近的两条途径——DNA修复和TGF-β信号传导，它们为酒精在癌症和干细胞调节方面提供了新的见解。
