Huff Sara B, Gottwald Lorie D
University of Toledo College of Medicine and Life Sciences, 3000 Arlington Avenue, Toledo, OH 43614, USA.
Department of Dermatology, University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH 43614, USA.
Case Rep Dermatol Med. 2017;2017:2386234. doi: 10.1155/2017/2386234. Epub 2017 Nov 6.
Vitiligo is a common pigment disorder characterized by acquired loss of function or absence of melanocytes, leading to distinct areas of depigmentation. Physical exam reveals sharply demarcated, depigmented macules or patches on otherwise normal skin. Vitiligo can present at any age, in any skin color. There is no specific serologic marker for diagnosis, but patients often have other autoimmune problems. Treatment options are limited and are difficult given the fact that the pathogenesis of the disease is not well elucidated. We present the case of a 52-year-old woman with vitiligo for over 2 decades. The patient's medical history reveals a lack of response to many different approaches. This case highlights the ability of apremilast, an FDA-approved drug for the treatment of psoriasis and psoriatic arthritis, to achieve repigmentation in a case a vitiligo that has been extremely recalcitrant.
白癜风是一种常见的色素紊乱疾病，其特征是黑素细胞获得性功能丧失或缺失，导致明显的色素脱失区域。体格检查发现，在原本正常的皮肤上有边界清晰的色素脱失斑疹或斑块。白癜风可在任何年龄、任何肤色人群中出现。目前尚无用于诊断的特异性血清学标志物，但患者常伴有其他自身免疫性问题。鉴于该疾病的发病机制尚未完全阐明，其治疗选择有限且困难。我们报告一例患白癜风20多年的52岁女性病例。患者的病史显示，她对多种不同的治疗方法均无反应。该病例突出了阿普米司特（一种已获美国食品药品监督管理局批准用于治疗银屑病和银屑病关节炎的药物）在一例极其难治的白癜风病例中实现色素再生的能力。
