Butler I J, Koslow S H, Seifert W E, Caprioli R M, Singer H S
Ann Neurol. 1979 Jul;6(1):37-9. doi: 10.1002/ana.410060109.
Biogenic amine metabolism in the central nervous system of 9 children with Tourette syndrome was evaluated by quantitation of their metabolites in cerebrospinal fluid by a gas chromatographic/mass spectrometric method. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) were measured in CSF before and after oral administration of probenecid. Dopamine metabolism appeared defective, as both baseline and accumulated levels of HVA after probenecid were decreased. Serotonin metabolism also appeared defective in some patients with low baseline and low accumulated levels of 5-HIAA after probenecid. Taken together with other clinical features of this disease, the results suggest an underlying disorder of dopamine and serotonin metabolism in Tourette syndrome.
采用气相色谱/质谱法对9例抽动秽语综合征患儿脑脊液中的代谢产物进行定量分析，以评估其中枢神经系统中的生物胺代谢情况。在口服丙磺舒前后，对脑脊液中的高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）和3-甲氧基-4-羟基苯乙二醇（MHPG）进行了测定。多巴胺代谢似乎存在缺陷，因为丙磺舒给药后的HVA基线水平和累积水平均降低。在一些患者中，5-HIAA的基线水平和丙磺舒给药后的累积水平较低，这表明5-羟色胺代谢也存在缺陷。结合该疾病的其他临床特征，结果提示抽动秽语综合征存在潜在的多巴胺和5-羟色胺代谢紊乱。
