Scheinin M
Med Biol. 1985;63(1):1-17.
Concentrations of monoamine metabolites in human cerebrospinal fluid (CSF) have been widely used as indicators of the level of functional activity in the central monoaminergic neuronal pathways. This article reviews the relationship between the turnover of the neurotransmitter monoamines noradrenaline, serotonin, and dopamine, and the concentrations in CSF of their principal metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA). It attempts to summarise what is known of the effects of various illnesses and drug treatments on the concentrations of these metabolites.
人脑脊液（CSF）中一元胺代谢物的浓度已被广泛用作中枢一元胺能神经元通路功能活动水平的指标。本文综述了神经递质去甲肾上腺素、血清素和多巴胺的周转率与其主要代谢物3-甲氧基-4-羟基苯乙二醇（MHPG）、5-羟基吲哚乙酸（5-HIAA）和高香草酸（HVA）在脑脊液中的浓度之间的关系。本文试图总结各种疾病和药物治疗对这些代谢物浓度的已知影响。
