Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India.
Analyst. 2018 Jan 15;143(2):528-535. doi: 10.1039/c7an01058c.
Chromogenic probe with oxidized bis-indolyl scaffold has been synthesized for the detection of a nerve gas mimicking agent, DCNP (diethyl cyanophosphonate) at pH 8.0 in water. The mechanism of interaction was proposed as the release of cyanide ion through the indole group mediating the hydrolysis of phosphorous-hetero atom bond and, thereafter, the Michael addition of the liberated CN ion to the electron deficient C[double bond, length as m-dash]C bond of the bis-indolyl moiety. The reaction featured a remarkable change in color from red to colorless at ambient condition. Then, low-cost and portable paper strips were designed for a rapid and on-site vapor phase detection of DCNP without involving any sophisticated instrument or skilled personnel. Finally, a dye assembled inorganic nanocomposite material was devised to achieve a more sensitive 'turn-on' detection of DCNP in water.
已合成了具有氧化双吲哚骨架的显色探针，用于在 pH 8.0 的水中检测神经毒气模拟剂 DCNP（二乙基氰膦酸酯）。相互作用的机制被提出为通过吲哚基团释放氰离子，介导磷杂原子键的水解，然后，释放的 CN 离子与双吲哚部分的缺电子 C[双键，长度为破折号]C 键发生迈克尔加成。该反应在环境条件下表现出从红色到无色的显著颜色变化。然后，设计了低成本和便携式纸条，用于快速和现场气相检测 DCNP，而不涉及任何复杂的仪器或熟练的人员。最后，设计了一种染料组装的无机纳米复合材料，以实现对水中 DCNP 的更灵敏的“开启”检测。
