基于咪唑并[1,2-a]吡啶的小分子有机荧光探针用于选择性检测神经毒剂模拟物。
Imidazo[1,2-a]pyridine based small organic fluorescent molecules for selective detection of nerve agents simulants.
机构信息
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Bijnor-Sisendi Road, Near CRPF Base Camp, Sarojini Nagar, Lucknow, Uttar Pradesh 226301, India.
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Bijnor-Sisendi Road, Near CRPF Base Camp, Sarojini Nagar, Lucknow, Uttar Pradesh 226301, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2022 Dec 5;282:121633. doi: 10.1016/j.saa.2022.121633. Epub 2022 Jul 16.
A fused heterocyclic ESIPT imidazo[1,2-a]pyridine-based probes for colorimetric and fluorometric detection of nerve agents simulant sarin (DCP) and tabun (DCNP) are reported. The probes (5b, 6a & 6b) were found to be highly sensitive and selective for the detection of DCNP and DCP at a micromolar concentration within seconds with no observed interference from other various types of analytes. The LOD for 6b towards DCP was found to be 0.6 µM with a linear range from 0 to 8 µM. The low-cost portable cellulose paper strip fabricated with probe 6b for real-time detection of DCP in the gas phase and spiked water has been developed. The paper strip product was found effective in detecting the presence of DCP in water and vapor state with substantial color changes which could be easily observed by the naked eye and under a handheld UV lamp at a wavelength of 365 nm.
一种融合的杂环 ESIPT 基于咪唑并[1,2-a]吡啶的探针，用于比色法和荧光法检测神经毒剂模拟物沙林（DCP）和塔崩（DCNP）。探针（5b、6a 和 6b）被发现对 DCNP 和 DCP 的检测具有高度的灵敏度和选择性，可在数秒内以微摩尔浓度检测，并且没有观察到其他各种类型的分析物的干扰。探针 6b 对 DCP 的检出限为 0.6 µM，线性范围为 0 至 8 µM。已经开发出一种用探针 6b 制造的低成本便携式纤维素纸条，用于实时检测气相和掺杂水中的 DCP。该纸条产品在检测水中和蒸气状态下 DCP 的存在方面非常有效，肉眼和手持 365nm 紫外灯下可以观察到明显的颜色变化。
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