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[用于检测高纯度产气荚膜梭菌类毒素疫苗质量和效力的血凝抑制试验]

[A hemagglutination inhibition test for control of the quality and effectiveness of highly-purified C. chauvoei toxoid vaccine].

作者信息

Roth F, Labarre B, Schmidt-Pannenbecker E

出版信息

Berl Munch Tierarztl Wochenschr. 1989 Jan 1;102(1):20-5.

PMID:2923618
Abstract

To control quality and efficiency of a highly purified C. chauvoei vaccine which has been developed in Göttingen a haemagglutination-inhibition test is presented. Laboratory and field trials did demonstrate the value of the test. Vaccinated guinea pigs which presented positive HIT titers survived the challenge. Cattle, vaccinated with the vaccine in Germany, Madagascar and Mexico showed positive titers which could be boostered through repeated vaccination.

摘要

为控制在哥廷根研发的高度纯化的肖维氏梭菌疫苗的质量和效率,现介绍一种血凝抑制试验。实验室和现场试验均证明了该试验的价值。血凝抑制试验(HIT)效价呈阳性的接种疫苗的豚鼠在攻毒后存活下来。在德国、马达加斯加和墨西哥接种该疫苗的牛,其效价呈阳性,且通过重复接种可提高效价。

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