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重度小儿阻塞性睡眠呼吸暂停患者行腺样体扁桃体切除术的疗效

Outcomes of adenotonsillectomy in severe pediatric obstructive sleep apnea.

作者信息

El-Kersh Karim, Cavallazzi Rodrigo, Senthilvel Egambaram

机构信息

Division of Pulmonary, Critical Care and Sleep Disorders Medicine, Department of Medicine, University of Louisville School of Medicine, Ambulatory Care Bldg., 550 S. Jackson St., Louisville, KY 40202, USA.

出版信息

Ear Nose Throat J. 2017 Dec;96(12):E6-E9. doi: 10.1177/014556131709601202.

Abstract

We conducted a retrospective chart review to examine the efficacy of adenotonsillectomy for the treatment of severe obstructive sleep apnea (OSA) in children. Our study population was made up of 85 patients-58 boys and 27 girls, aged 1 to 17 years (mean: 6.9 ± 4.4)-with severe OSA who had undergone adenotonsillectomy and pre- and postoperative attended polysomnography (PSG) over a 4-year period. Severe OSA was defined as an apnea-hypopnea index (AHI) of >10 events per hour of sleep. Patients who had an underlying genetic or craniofacial anomaly were excluded. In addition to demographic and PSG data, we compiled information on selected characteristics of patients according to postoperative residual AHIs of ≤5 and >5. Finally, information on body mass index z score was available on 72 patients; the mean score was 1.55 ± 1.51, with 36 patients (50.0%) fulfilling the criteria for obesity. In the group as a whole, we found that adenotonsillectomy resulted in a significant reduction in AHI from 35.4 to 7.1 (p < 0.001). We also found an improvement in mean oxygen saturation nadir from 75.2 to 85.5 (p < 0.001). Postoperatively, only 8 patients (9.4%) achieved an AHI of ≤1; AHIs were >1 to ≤5 in 39 patients (45.9%), >5 to ≤10 in 24 patients (28.2%), and >10 in 14 patients (16.5%). A significantly higher proportion of boys had a residual AHI of >5 after surgery compared with those whose postoperative AHI was ≤5 (78.9 vs. 59.6%; p = 0.04). We conclude that adenotonsillectomy leads to a significant improvement in sleep-disordered breathing in children with severe OSA, but residual disease is common so close postoperative follow-up is essential.

摘要

我们进行了一项回顾性病历审查,以研究腺样体扁桃体切除术治疗儿童重度阻塞性睡眠呼吸暂停(OSA)的疗效。我们的研究对象包括85例重度OSA患儿,其中58例为男孩,27例为女孩,年龄在1至17岁之间(平均年龄:6.9±4.4岁),他们在4年期间接受了腺样体扁桃体切除术,并在术前和术后进行了多导睡眠图(PSG)检查。重度OSA定义为睡眠呼吸暂停低通气指数(AHI)每小时睡眠中大于10次事件。有潜在遗传或颅面畸形的患者被排除在外。除了人口统计学和PSG数据外,我们还根据术后残余AHI≤5和>5收集了患者的选定特征信息。最后,72例患者有体重指数z评分信息;平均评分为1.55±1.51,36例患者(50.0%)符合肥胖标准。在整个研究组中,我们发现腺样体扁桃体切除术使AHI从35.4显著降低至7.1(p<0.001)。我们还发现平均最低血氧饱和度从75.2提高到85.5(p<0.001)。术后,只有8例患者(9.4%)的AHI≤1;39例患者(45.9%)的AHI>1至≤5,24例患者(28.2%)的AHI>5至≤10,14例患者(16.5%)的AHI>10。与术后AHI≤5的患者相比,术后残余AHI>5的男孩比例显著更高(78.9%对59.6%;p=0.04)。我们得出结论,腺样体扁桃体切除术可使重度OSA儿童的睡眠呼吸障碍得到显著改善,但残余疾病很常见,因此术后密切随访至关重要。

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