Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
Molecular Diagnostics, Genetix Biotech Asia (P) Ltd., New Delhi, India.
J Cell Biochem. 2018 Jul;119(7):5186-5221. doi: 10.1002/jcb.26554. Epub 2018 Mar 25.
The intriguing molecular pathways involved in oral carcinogenesis are still ambiguous. The oral squamous cell carcinoma (OSCC) ranks as the most common type constituting more than 90% of the globally diagnosed oral cancers cases. The elevation in the OSCC incidence rate during past 10 years has an alarming impression on human healthcare. The major challenges associated with OSCC include delayed diagnosis, high metastatic rates, and low 5-year survival rates. The present work foundations on reverse genetic strategy and involves the identification of genes showing expressional variability in an OSCC case lacking addictive proclivities for tobacco, betel nut, and/or alcohol, major etiologies. The expression modulations in the identified genes were analyzed in 16 patients comprising oral pre-cancer and cancer histo-pathologies. The genes SCCA1 and KRT1 were found to down regulate while DNAJC13, GIPC2, MRPL17, IG-Vreg, SSFA2, and UPF0415 upregulated in the oral pre-cancer and cancer pathologies, implicating the genes as crucial players in oral carcinogenesis.
口腔癌发生中涉及的有趣分子途径仍然不清楚。口腔鳞状细胞癌（OSCC）是最常见的类型，占全球诊断出的口腔癌病例的 90%以上。在过去 10 年中，OSCC 的发病率上升给人类健康带来了令人震惊的影响。OSCC 相关的主要挑战包括诊断延迟、高转移率和低 5 年生存率。本工作基于反向遗传学策略，涉及鉴定在一个没有吸烟、槟榔和/或酒精成瘾倾向的 OSCC 病例中表现出表达变异性的基因，这些是主要的病因。在 16 名包括口腔癌前病变和癌症组织病理学的患者中分析了鉴定基因的表达调节。发现 SCCA1 和 KRT1 下调，而 DNAJC13、GIPC2、MRPL17、IG-Vreg、SSFA2 和 UPF0415 在口腔癌前病变和癌症病变中上调，表明这些基因是口腔癌发生的关键因素。
