Faraji Samaneh, Sharafi Mohsen, Shahverdi Abdol Hossein, Fathi Rouhollah
Department of Molecular and Cellular Biology, Faculty of Basic Science and Advanced Technologies in Biology, University of Science and Culture, ACECR, Tehran, Iran.
. Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Cell J. 2021 Oct;23(5):495-502. doi: 10.22074/cellj.2021.7377. Epub 2021 Oct 30.
Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have explored several new properties of SPAGs and shed light on sperm's function, the impact of anti-sperm antibodies (ASA) in immunological infertility, and some tumors related to SPAGs. This article presents an exhaustive review of SPAGs and their roles in the cell cycle, signaling pathways, fertility, sperm-oocyte cross-talk as well as their unfavorable positions as prognostic factors in many types of cancers.
精子相关抗原（SPAGs）在功能和进化方面是特定的蛋白质，在睾丸或精子细胞中普遍表达。此外，针对某些SPAGs的体液免疫反应可导致免疫性不育。另一方面，最近的研究探索了SPAGs的一些新特性，并揭示了精子的功能、抗精子抗体（ASA）在免疫性不育中的影响以及一些与SPAGs相关的肿瘤。本文对SPAGs及其在细胞周期、信号通路、生育能力、精子-卵母细胞相互作用中的作用，以及它们在多种癌症中作为预后因素的不利地位进行了详尽综述。
