Leitner D S
Department of Psychology, St. Joseph's University, Philadelphia, Pennsylvania 19131-1395.
Behav Neurosci. 1989 Feb;103(1):151-7. doi: 10.1037//0735-7044.103.1.151.
Cold swim stress and morphine administration produce analgesia. Whether this was accompanied by changes in other senses was investigated. Analgesia was assessed with a tail-flick test; the sensitivity of the other senses was assessed using the ability of mild sensory stimuli (prestimuli) to inhibit the amplitude of a subsequently elicited acoustic startle response. In Experiment 1, auditory prestimuli were used. In Experiment 2, visual prestimuli were used. In each experiment, rats were exposed to cold-water swims followed by behavioral testing, warm swims followed by testing, and testing alone. This was repeated, substituting morphine injections followed by testing, vehicle injections followed by testing, or testing alone. Both cold swim stress and morphine produced reliable analgesia. Only cold swim stress interfered with the ability of the stimuli to inhibit startle. This reflects decreased sensitivity to auditory and visual stimulation caused by cold swim stress, which suggests that the resultant sensory deficits are more global than is currently believed.
冷水游泳应激和注射吗啡均可产生镇痛作用。本研究调查了这一过程中其他感觉是否发生变化。通过甩尾试验评估镇痛效果；使用轻度感觉刺激（预刺激）抑制随后引发的听觉惊吓反应幅度的能力来评估其他感觉的敏感性。在实验1中，使用听觉预刺激。在实验2中，使用视觉预刺激。在每个实验中，大鼠先进行冷水游泳，随后进行行为测试，再进行温水游泳并测试，最后单独进行测试。重复上述操作，替换为注射吗啡后测试、注射赋形剂后测试或单独测试。冷水游泳应激和吗啡均产生了可靠的镇痛作用。只有冷水游泳应激会干扰刺激抑制惊吓反应的能力。这反映出冷水游泳应激导致对听觉和视觉刺激的敏感性降低，这表明由此产生的感觉缺陷比目前认为的更为普遍。
