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本文引用的文献

1
Why Alcoholics Ought to Compete Equally for Liver Transplants.
Bioethics. 2016 Nov;30(9):689-697. doi: 10.1111/bioe.12274. Epub 2016 Aug 12.
2
Three-year Results of a Pilot Program in Early Liver Transplantation for Severe Alcoholic Hepatitis.严重酒精性肝炎早期肝移植试点项目的三年结果
Ann Surg. 2017 Jan;265(1):20-29. doi: 10.1097/SLA.0000000000001831.
3
Liver Transplantation for Alcoholic and Nonalcoholic Fatty Liver Disease: Pretransplant Selection and Posttransplant Management.肝移植治疗酒精性和非酒精性脂肪性肝病:移植前选择和移植后管理。
Gastroenterology. 2016 Jun;150(8):1849-62. doi: 10.1053/j.gastro.2016.02.077. Epub 2016 Mar 10.
4
Treatment of Severe Alcoholic Hepatitis.重症酒精性肝炎的治疗
Gastroenterology. 2016 Jun;150(8):1823-34. doi: 10.1053/j.gastro.2016.02.074. Epub 2016 Mar 4.
5
Early Liver Transplantation for Severe Alcoholic Hepatitis in the United States--A Single-Center Experience.美国重症酒精性肝炎的早期肝移植——单中心经验。
Am J Transplant. 2016 Mar;16(3):841-9. doi: 10.1111/ajt.13586. Epub 2015 Dec 28.
6
Recurrent alcoholic cirrhosis in severe alcoholic relapse after liver transplantation: a frequent and serious complication.肝移植后严重酒精性复发中的复发性酒精性肝硬化:一种常见且严重的并发症。
Am J Gastroenterol. 2015 Aug;110(8):1160-6; quiz 1167. doi: 10.1038/ajg.2015.204. Epub 2015 Jul 14.
7
Comparative Effectiveness of Pharmacological Interventions for Severe Alcoholic Hepatitis: A Systematic Review and Network Meta-analysis.药物干预治疗重症酒精性肝炎的疗效比较:系统评价和网络荟萃分析。
Gastroenterology. 2015 Oct;149(4):958-70.e12. doi: 10.1053/j.gastro.2015.06.006. Epub 2015 Jun 16.
8
Prednisolone or pentoxifylline for alcoholic hepatitis.泼尼松龙或己酮可可碱治疗酒精性肝炎。
N Engl J Med. 2015 Apr 23;372(17):1619-28. doi: 10.1056/NEJMoa1412278.
9
Liver transplantation for alcoholic liver disease.肝移植治疗酒精性肝病。
Nat Rev Gastroenterol Hepatol. 2014 May;11(5):300-7. doi: 10.1038/nrgastro.2013.247. Epub 2014 Jan 7.
10
Consequences of perceived stigma among patients with cirrhosis.肝硬化患者感知到的耻辱感的后果。
Dig Dis Sci. 2014 Mar;59(3):681-6. doi: 10.1007/s10620-013-2942-0. Epub 2013 Nov 19.

酒精性肝病的肝移植:公平吗?

Transplantation for Alcohol-related Liver Disease: Is It Fair?

作者信息

Mellinger Jessica L, Volk Michael L

机构信息

Division of Gastroenterology, University of Michigan Hospitals, 1500 Medical Center Dr., 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109-5362, USA.

Division of Gastroenterology and Transplantation Institute, Loma Linda University Medical, Loma Linda University Health, 25865 Barton Road, Suite 101, Loma Linda, CA 92354, USA.

出版信息

Alcohol Alcohol. 2018 Mar 1;53(2):173-177. doi: 10.1093/alcalc/agx105.

DOI:10.1093/alcalc/agx105
PMID:29236944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6355095/
Abstract

AIMS

Alcohol-related liver disease (ALD) is the second leading cause of liver transplantation performed in the USA and Europe. We aimed to provide a narrative review of the major ethical issues governing transplantation for ALD.

METHODS

We performed a narrative review of the ethical concepts in organ allocation for ALD, including alcoholic hepatitis.

RESULTS

Ethical concerns regarding organ allocation for ALD involve issues of urgency, utility and justice. Post-transplant outcomes for ALD patients are good and ethical considerations limiting organs solely because of alcohol etiology do not bear scrutiny.

CONCLUSION

ALD will continue to be a major cause for liver failure. The main criteria for transplant in ALD should be the patient's risk of return to harmful drinking, alongside standard assessments of physical and psychosocial fitness for transplant.

摘要

目的

酒精性肝病(ALD)是美国和欧洲进行肝移植的第二大主要原因。我们旨在对ALD移植的主要伦理问题进行叙述性综述。

方法

我们对ALD(包括酒精性肝炎)器官分配中的伦理概念进行了叙述性综述。

结果

关于ALD器官分配的伦理问题涉及紧迫性、效用和公平性。ALD患者移植后的结果良好,仅因酒精病因限制器官的伦理考量经不起推敲。

结论

ALD将继续是肝衰竭的主要原因。ALD移植的主要标准应是患者恢复有害饮酒的风险,以及对移植身体和心理社会适应性的标准评估。