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在分配因酒精相关终末期肝病而患病的患者的已故供体器官时,是否应该使用责任作为打破平局的因素?

Should responsibility be used as a tiebreaker in allocation of deceased donor organs for patients suffering from alcohol-related end-stage liver disease?

机构信息

Department of Philosophy, Central South University, 410075, Changsha, China.

Institute of History and Ethics of Medicine, Medical Department, Heidelberg University, Im Neuenheimer Feld 327, 69120, Heidelberg, Germany.

出版信息

Med Health Care Philos. 2023 Jun;26(2):243-255. doi: 10.1007/s11019-023-10141-3. Epub 2023 Feb 13.

Abstract

There is a long-standing debate concerning the eligibility of patients suffering from alcohol-related end-stage liver disease (ARESLD) for deceased donor liver transplantation. The question of retrospective and/or prospective responsibility has been at the center of the ethical discussion. Several authors argue that these patients should at least be regarded as partly responsible for their ARESLD. At the same time, the arguments for retrospective and/or prospective responsibility have been strongly criticized, such that no consensus has been reached. A third option was proposed as a form of compromise, namely that responsibility should only be used as a tiebreaker in liver allocation. The present study provides an ethical investigation of this third option. First, we will provide an overview of the main arguments that have been offered for and against the use of responsibility as an allocation criterion. Second, we will explore the concept of responsibility as a tiebreaker in detail and discuss several types of situations, in which responsibility could be used as a tiebreaker, as well as the main ethical challenges associated with them. As we will show, an ethical justified use of responsibility as a tiebreaker is limited to a very restricted number of cases and is associated with a number of ethical concerns. For this reason, waiting time should be preferred as a tiebreaker in liver allocation, even though the criterion of waiting time, too, raises a number of equity-related concerns.

摘要

关于患有酒精相关终末期肝病 (ARESLD) 的患者是否有资格接受已故供体肝移植,一直存在着长期的争论。回溯责任和/或前瞻性责任的问题一直是伦理讨论的核心。一些作者认为,这些患者至少应该被视为对其 ARESLD 负有部分责任。与此同时,回溯责任和/或前瞻性责任的论点受到了强烈批评,因此尚未达成共识。第三种选择被提出作为一种妥协,即责任只能作为肝脏分配的决胜局。本研究对第三种选择进行了伦理调查。首先,我们将概述支持和反对将责任作为分配标准的主要论点。其次,我们将详细探讨责任作为决胜局的概念,并讨论几种情况下可以使用责任作为决胜局的情况,以及与之相关的主要伦理挑战。正如我们将展示的那样,将责任作为决胜局的有理由的使用仅限于非常有限的情况,并伴随着一些伦理问题。因此,即使等待时间标准也会引起一些与公平相关的问题,等待时间也应作为肝脏分配的决胜局。

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