慢性乙肝感染患者血清中白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α和转化生长因子-β的水平：抑郁和焦虑的影响
Serum Levels of IL-6, IL-8, TNF-α, and TGF-β in Chronic HBV-Infected Patients: Effect of Depression and Anxiety.
作者信息
Bahramabadi Reza, Fathollahi Mahmood Sheikh, Hashemi Seyyed Mohammad, Arababadi Amin Safari, Arababadi Minoo Safari, Yousefi-Daredor Hassan, Bidaki Reza, Khaleghinia Mehdi, Bakhshi Mohammad Hossein, Yousefpoor Yaser, Torbaghan Yaser Eskandari, Arababadi Mohammad Kazemi
机构信息
Immunology of Infectious Diseases Research Center, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Immunology, Faculty of Medicine, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
出版信息
Lab Med. 2017 Dec 22;49(1):41-46. doi: 10.1093/labmed/lmx064.
OBJECTIVE
To assess the effects of depression and anxiety on serum cytokine levels in patients with chronic hepatitis B (CHB) infection.
METHODS
In this cross-sectional study, 60 healthy control individuals and 60 patients with CHB participated after filling out standard questionnaires. We examined their serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and TGF-β levels using enzyme-linked immunosorbent assay (ELISA) techniques.
RESULTS
In patients with CHB compared with healthy controls, serum levels of IL-8 were significantly increased, whereas IL-6 and TGF-β levels were significantly decreased. Serum levels of TGF-β were significantly decreased in the patients with CHB who had mild depression, compared with patients with CHB without depression and with moderate and severe depression.
CONCLUSIONS
Downregulation of IL-8 and TGF-β, respectively, is a corresponding mechanism for induction of chronic inflammation in patients with CHB. Depression also seems to induce inflammation via downregulation of TGF-β in these patients.
目的
评估抑郁和焦虑对慢性乙型肝炎（CHB）感染患者血清细胞因子水平的影响。
方法
在这项横断面研究中，60名健康对照个体和60名CHB患者在填写标准问卷后参与研究。我们使用酶联免疫吸附测定（ELISA）技术检测了他们的血清白细胞介素（IL）-6、IL-8、肿瘤坏死因子（TNF）-α和转化生长因子（TGF）-β水平。
结果
与健康对照相比，CHB患者血清IL-8水平显著升高，而IL-6和TGF-β水平显著降低。与无抑郁的CHB患者以及中度和重度抑郁的CHB患者相比，轻度抑郁的CHB患者血清TGF-β水平显著降低。
结论
IL-8和TGF-β的下调分别是CHB患者慢性炎症诱导的相应机制。抑郁似乎也通过下调这些患者的TGF-β诱导炎症。
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